SLC26A11 and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SLC26A11	C5AR2
Description		solute carrier family 26 member 11	complement C5a receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extracellular Exosome	Plasma Membrane Basal Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Chloride Channel Activity Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Antiporter Activity Chloride:bicarbonate Antiporter Activity	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Monoatomic Ion Transport Oxalate Transport Transmembrane Transport Inorganic Anion Transmembrane Transport Sulfate Transmembrane Transport Chloride Transmembrane Transport	Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis
Pathways		Transport and metabolism of PAPS Inorganic anion exchange by SLC26 transporters	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		Interleukin-1-receptor antagonist levels ( 22205395) Ischemic stroke ( 26732560)
Interacting Genes		3 interacting genes: C5AR2 CFTR SMIM1	17 interacting genes: ABCA7 ACO2 ARLN C3 C4A C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		284129	27202
HPRD ID		11569	17072
Ensembl ID		ENSG00000181045	ENSG00000134830
Uniprot IDs		Q86WA9	Q9P296
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Complement Component C5a Receptor Activity Positive Regulation Of Enamel Mineralization Complement Component C5a Signaling Pathway Transepithelial Water Transport Negative Regulation Of Neutrophil Chemotaxis Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Neutrophil Migration Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Complement Receptor Activity Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Complement Receptor Mediated Signaling Pathway Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Negative Regulation Of Leukocyte Chemotaxis Cell Surface Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Regulation Of Neutrophil Chemotaxis Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Regulation Of Neutrophil Migration Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Chemotaxis Negative Regulation Of Interleukin-6 Production	Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Classical-complement-pathway C3/C5 Convertase Complex Amyloid-beta Clearance Regulation Of Endocytosis Positive Regulation Of Phagocytosis Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Opsonization Regulation Of Phagocytosis Regulation Of Vesicle-mediated Transport Symbiont Cell Surface Transmembrane Transporter Binding Locomotion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endocytosis Antigen Binding Complement Activation, Classical Pathway Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Endopeptidase Inhibitor Activity Plasma Membrane Presynaptic Endocytosis Corticospinal Neuron Axon Guidance Oxoglutarate:malate Antiporter Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Complement Activation Positive Regulation Of Activation Of Membrane Attack Complex Basolateral Plasma Membrane Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Positive Regulation Of Voltage-gated Sodium Channel Activity Apolipoprotein A-I Receptor Activity Positive Regulation Of Engulfment Of Apoptotic Cell Regulation Of Engulfment Of Apoptotic Cell Scrib-APC-beta-catenin Complex
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