CXCR3 and VCAN

Number of citations of the paper that reports this interaction (PMID 11083865)
32

Data Source:
BioGRID (pull down)

		CXCR3	VCAN
Gene Name		chemokine (C-X-C motif) receptor 3	versican
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-X-C Chemokine Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Leukocyte Migration Apoptotic Process Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation T Cell Chemotaxis Negative Regulation Of Angiogenesis Calcium-mediated Signaling Positive Regulation Of CAMP Metabolic Process Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 11 Production Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Skeletal System Development Osteoblast Differentiation Carbohydrate Metabolic Process Cell Adhesion Multicellular Organismal Development Central Nervous System Development Heart Development Cell Recognition Glial Cell Migration Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS			Major depressive disorder ( 20516156)
Protein-Protein Interactions		6 interactors: CXCL10 CXCL11 CXCL13 CXCL9 PF4 VCAN	24 interactors: ACAN ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 CXCR3 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A SELL SELP SELPLG TNR XCL1
Entrez ID		2833	1462
HPRD ID		02936	00340
Ensembl ID		ENSG00000186810	ENSG00000038427
Uniprot IDs		P49682	P13611 Q59FG9 Q6MZK8 Q86W61
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of CAMP-mediated Signaling Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of CAMP-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Lymphocyte Migration Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior Leukocyte Migration T Cell Chemotaxis Positive Regulation Of CAMP Metabolic Process Cell Migration Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of CAMP Metabolic Process T Cell Migration Inflammatory Response Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Locomotion Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Lipid Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Immune System Process Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Calcium Ion Transport G-protein Coupled Receptor Signaling Pathway	Leukocyte Migration Cell Migration Cell Motility Regulation Of Leukocyte Migration Locomotion Positive Regulation Of Leukocyte Migration Cell Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Behavior Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Regulation Of Chemotaxis Regulation Of Cell Migration Inflammatory Response Regulation Of Cell Motility Immune System Process Regulation Of Behavior Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Chemokine-mediated Signaling Pathway Response To Other Organism Extracellular Matrix Organization Extracellular Structure Organization Response To Biotic Stimulus Regulation Of Immune System Process Cellular Extravasation Lymphocyte Migration Response To External Stimulus Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Single Organismal Cell-cell Adhesion Response To Organic Substance Defense Response Positive Regulation Of Cell Adhesion Lymphocyte Chemotaxis T Cell Migration Cellular Response To Cytokine Stimulus
Tagcloud ?		allergic cc ccr1 ccr3 ccr4 ccr5 chemokine chemokines coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt
Tagcloud (Difference) ?		allergic cc ccr1 ccr3 ccr4 ccr5 chemokine chemokines coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt
Tagcloud (Intersection) ?