CRACR2B and RIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRACR2B	RIN1
Description		calcium release activated channel regulator 2B	Ras and Rab interactor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Store-operated Calcium Entry	Endocytosis Signal Transduction Vesicle-mediated Transport Intracellular Signal Transduction
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Body mass index ( 29273807)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		16 interacting genes: APP CA13 CCDC187 CFTR DNAAF4 IDH1 IL36RN LNX1 PSMB3 RIN1 TCEANC TSGA10IP TSHZ2 TXN2 USP2 ZBTB25	49 interacting genes: ABL1 ABL2 AFDN ANKS1A ANKS1B CALCOCO2 CAPNS2 CARD10 CRACR2B EGFR EIF3F ERBB2 ERBB3 GOLGA2 GOLGA6L9 HMG20A HRAS HSF2BP ITSN1 KLHL12 KRT34 KRTAP13-1 KRTAP15-1 LZTS2 MDFI MTDH PICK1 PLEKHG4 RAB5A RAB5B RALGDS RRAS2 SEC23B SH3RF1 SNX17 SORBS3 SPRED1 TBC1D1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM7 TRIP10 TSC1 YWHAB YWHAE YWHAZ ZBED1
Entrez ID		283229	9610
HPRD ID		14645	05813
Ensembl ID		ENSG00000177685	ENSG00000174791
Uniprot IDs		Q8N4Y2	A0A0S2Z4T5 A0A0S2Z4U0 Q13671
PDB IDs
Enriched GO Terms of Interacting Partners?		Antifungal Humoral Response	Cytosol Cytoplasm Perinuclear Region Of Cytoplasm Phosphoserine Residue Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAPK Cascade ERBB Signaling Pathway GDP Binding Intracellular Signaling Cassette MAPK Cascade Identical Protein Binding Regulation Of Intracellular Signal Transduction Protein Sequestering Activity ERBB3:ERBB2 Complex Regulation Of Autophagy Melanosome Positive Regulation Of Intracellular Signal Transduction Cellular Localization Vesicle-mediated Transport Schwann Cell Development Protein Tyrosine Kinase Activity Glial Cell Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Protein Localization Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Binding Establishment Of Localization In Cell Regulation Of Cell Communication Signal Transduction Regulation Of Signaling ErbB-3 Class Receptor Binding Regulation Of Cellular Component Organization Intracellular Transport Regulation Of Actin Filament-based Process Protein Binding Regulation Of Establishment Of T Cell Polarity Regulation Of Signal Transduction Protein Modification Process Regulation Of Fibroblast Proliferation Regulation Of ERK1 And ERK2 Cascade Protein Phosphatase Binding Myelination Axon Ensheathment Regulation Of Protein Localization Negative Regulation Of Signaling Negative Regulation Of Cell Communication ERBB2-EGFR Signaling Pathway
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