XCR1 and XCL1

Number of citations of the paper that reports this interaction (PMID 9632725)
25

Data Source:
HPRD (in vivo)

		XCR1	XCL1
Gene Name		chemokine (C motif) receptor 1	chemokine (C motif) ligand 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity	Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity
	Biological Process	Chemotaxis Inflammatory Response G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Interleukin-4 Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: XCL1 XCL2	3 interactors: KRTAP10-3 VCAN XCR1
Entrez ID		2829	6375
HPRD ID		02774	02595
Ensembl ID		ENSG00000173578	ENSG00000143184
Uniprot IDs		P46094 Q502V0 Q689E2	P47992
PDB IDs			1J8I 1J9O 2HDM 2JP1 2NYZ
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Positive Regulation Of T-helper 1 Cell Cytokine Production Mature Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme B Production Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Thymocyte Migration Natural Killer Cell Chemotaxis Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of B Cell Chemotaxis Chemotaxis Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Alpha-beta T Cell Proliferation Cell Migration Lymphocyte Chemotaxis Cell Motility Positive Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Migration Negative Regulation Of Interleukin-2 Production Regulation Of T Cell Migration Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Alpha-beta T Cell Activation Regulation Of T Cell Cytokine Production Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Type 2 Immune Response Regulation Of Neutrophil Chemotaxis Lymphocyte Migration Positive Regulation Of Interleukin-10 Production Regulation Of Neutrophil Migration Regulation Of Lymphocyte Migration Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Locomotion Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Interferon-gamma Production Release Of Sequestered Calcium Ion Into Cytosol Immune Response Regulation Of Granulocyte Chemotaxis	Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Locomotion Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chemokine-mediated Signaling Pathway Chondroitin Sulfate Metabolic Process Glial Cell Migration Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process
Tagcloud ?		12p70 9a abs adjuvants cadm1 cd141 cd1c counterparts dc dec dissect flt3 humanized incorporating lambda lectin lesser pdc phenotypically plasmacytoid polycytidylic polyinosinic producers reconstitution spleen subsets tlr3 tlr4 tlr9	17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14
Tagcloud (Difference) ?		12p70 9a abs adjuvants cadm1 cd141 cd1c counterparts dc dec dissect flt3 humanized incorporating lambda lectin lesser pdc phenotypically plasmacytoid polycytidylic polyinosinic producers reconstitution spleen subsets tlr3 tlr4 tlr9	17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14
Tagcloud (Intersection) ?