XCR1 and TOPAZ1

Data Source: HiPPIP (Novel)

		XCR1	TOPAZ1
Name		X-C motif chemokine receptor 1	testis and ovary specific TOPAZ 1
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Cytosol
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	None
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Response To Cytokine Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Chemokine-mediated Signaling Pathway	Apoptotic Process Spermatogenesis Cell Differentiation Ectopic Germ Cell Programmed Cell Death Spermatocyte Division LncRNA Transcription
Pathways		Chemokine receptors bind chemokines G alpha (q) signalling events	None
GWAS		Aspartate aminotransferase levels ( 33547301 ) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485 ) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485 )	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Depression ( 29700475 ) General risk tolerance (MTAG) ( 30643258 )
Interacting Genes		3 interacting genes: PLEKHF2 XCL1 XCL2	None recorded
Entrez ID		2829	375337
HPRD ID		02774	19563
Ensembl ID		ENSG00000173578	ENSG00000173769
Uniprot IDs		P46094 Q502V0 Q689E2	Q8N9V7
PDB IDs		9AST	Not available
GO Terms Enriched among Interactors		CCR Chemokine Receptor Binding Positive Regulation Of Granzyme A Production Chemokine Activity Negative Regulation Of T-helper 1 Cell Activation Chemokine-mediated Signaling Pathway Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Granzyme B Production Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Thymocyte Migration Spermatocyte Division G Protein-coupled Receptor Signaling Pathway Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Natural Killer Cell Chemotaxis Regulation Of Thymocyte Migration Antimicrobial Humoral Response LncRNA Transcription Positive Regulation Of Natural Killer Cell Chemotaxis Cell Chemotaxis Cytokine Activity CAMP-dependent Protein Kinase Regulator Activity Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Humoral Immune Response Regulation Of CD8-positive, Alpha-beta T Cell Proliferation CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T-helper 2 Cell Cytokine Production Chemokine Receptor Binding Nucleotide-activated Protein Kinase Complex Negative Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Chemotaxis Protein Kinase A Catalytic Subunit Binding Positive Regulation Of T Cell Chemotaxis Locomotion Regulation Of T Cell Chemotaxis Negative Regulation Of Alpha-beta T Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type 2 Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of T-helper 1 Type Immune Response Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Lymphocyte Chemotaxis Ectopic Germ Cell Programmed Cell Death CAMP Binding Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Regulation Of Muscle Filament Sliding Speed Diaphragm Contraction Troponin I Binding Regulation Of Muscle Filament Sliding Troponin T Binding Cardiac Troponin Complex Involuntary Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Regulation Of Protein Monoubiquitination Deubiquitinase Activator Activity Negative Regulation Of Stress-activated MAPK Cascade Troponin Complex Cardiac Muscle Cell Contraction Aminoacyl-tRNA Synthetase Multienzyme Complex Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Skeletal Muscle Adaptation