XCR1

Description		X-C motif chemokine receptor 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Response To Cytokine Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (q) signalling events
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Novel Interacting Genes		2 novel interacting genes: PRKAR2A TOPAZ1
Interacting Genes		3 interacting genes: PLEKHF2 XCL1 XCL2
Entrez ID		2829
HPRD ID		02774
Ensembl ID		ENSG00000173578
Uniprot IDs		P46094 Q502V0 Q689E2
PDB IDs		9AST
Enriched GO Terms of Interacting Partners?		CCR Chemokine Receptor Binding Positive Regulation Of Granzyme A Production Chemokine Activity Negative Regulation Of T-helper 1 Cell Activation Chemokine-mediated Signaling Pathway Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Granzyme B Production Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Thymocyte Migration Spermatocyte Division G Protein-coupled Receptor Signaling Pathway Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Natural Killer Cell Chemotaxis Regulation Of Thymocyte Migration Antimicrobial Humoral Response LncRNA Transcription Positive Regulation Of Natural Killer Cell Chemotaxis Cell Chemotaxis Cytokine Activity CAMP-dependent Protein Kinase Regulator Activity Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Humoral Immune Response Regulation Of CD8-positive, Alpha-beta T Cell Proliferation CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T-helper 2 Cell Cytokine Production Chemokine Receptor Binding Nucleotide-activated Protein Kinase Complex Negative Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Chemotaxis Protein Kinase A Catalytic Subunit Binding Positive Regulation Of T Cell Chemotaxis Locomotion Regulation Of T Cell Chemotaxis Negative Regulation Of Alpha-beta T Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type 2 Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of T-helper 1 Type Immune Response Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Lymphocyte Chemotaxis Ectopic Germ Cell Programmed Cell Death CAMP Binding Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
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