XCR1 and XCL2

Number of citations of the paper that reports this interaction (PMID 9632725)
25

Data Source:
HPRD (in vivo)

		XCR1	XCL2
Gene Name		chemokine (C motif) receptor 1	chemokine (C motif) ligand 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity	Chemokine Activity
	Biological Process	Chemotaxis Inflammatory Response G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway	Immune Response Signal Transduction Blood Circulation Cell Chemotaxis
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: XCL1 XCL2	3 interactors: KRTAP10-9 NOTCH2NL XCR1
Entrez ID		2829	6846
HPRD ID		02774	05317
Ensembl ID		ENSG00000173578	ENSG00000143185
Uniprot IDs		P46094 Q502V0 Q689E2	Q9UBD3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Positive Regulation Of T-helper 1 Cell Cytokine Production Mature Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme B Production Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Thymocyte Migration Natural Killer Cell Chemotaxis Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of B Cell Chemotaxis Chemotaxis Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Alpha-beta T Cell Proliferation Cell Migration Lymphocyte Chemotaxis Cell Motility Positive Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Migration Negative Regulation Of Interleukin-2 Production Regulation Of T Cell Migration Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Alpha-beta T Cell Activation Regulation Of T Cell Cytokine Production Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Type 2 Immune Response Regulation Of Neutrophil Chemotaxis Lymphocyte Migration Positive Regulation Of Interleukin-10 Production Regulation Of Neutrophil Migration Regulation Of Lymphocyte Migration Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Locomotion Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Interferon-gamma Production Release Of Sequestered Calcium Ion Into Cytosol Immune Response Regulation Of Granulocyte Chemotaxis	Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport
Tagcloud ?		12p70 9a abs adjuvants cadm1 cd141 cd1c counterparts dc dec dissect flt3 humanized incorporating lambda lectin lesser pdc phenotypically plasmacytoid polycytidylic polyinosinic producers reconstitution spleen subsets tlr3 tlr4 tlr9	assayed buck chose clic5 conditional cxcl13 dichotomization dichotomous dr ffpe hrneg hrpos ics incorporating microarray multigene multiplexed nodal optimized platforms prognostically proved reaffirmed rtpcr signatures subtyping tneg tnfrsf17 today
Tagcloud (Difference) ?		12p70 9a abs adjuvants cadm1 cd141 cd1c counterparts dc dec dissect flt3 humanized lambda lectin lesser pdc phenotypically plasmacytoid polycytidylic polyinosinic producers reconstitution spleen subsets tlr3 tlr4 tlr9	assayed buck chose clic5 conditional cxcl13 dichotomization dichotomous dr ffpe hrneg hrpos ics microarray multigene multiplexed nodal optimized platforms prognostically proved reaffirmed rtpcr signatures subtyping tneg tnfrsf17 today
Tagcloud (Intersection) ?		incorporating