GP5 and GP1BA

Number of citations of the paper that reports this interaction (PMID 1730602)
20

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GP5	GP1BA
Gene Name		glycoprotein V (platelet)	glycoprotein Ib (platelet), alpha polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Anchored Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Collagen Binding	Protein Binding Thrombin Receptor Activity
	Biological Process	Cell Adhesion Cell-matrix Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Platelet Activation Platelet Activation	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Thrombin Receptor Signaling Pathway
Pathways		Platelet Adhesion to exposed collagen Intrinsic Pathway GP1b-IX-V activation signalling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade)
Drugs			Alpha-D-Mannose
Diseases
GWAS			Platelet counts ( 22139419 20139978)
Protein-Protein Interactions		3 interactors: F2 GP1BA YWHAZ	16 interactors: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP SELP TPST1 VWF YWHAZ
Entrez ID		2814	2811
HPRD ID		01431	01976
Ensembl ID		ENSG00000178732	ENSG00000185245
Uniprot IDs		D1MER9 P40197	E7ES66
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation, Intrinsic Pathway Fibrinolysis Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Negative Regulation Of Blood Coagulation Wound Healing Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Cell Activation Response To Wounding Regulation Of Blood Coagulation Regulation Of Wound Healing Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Protein Activation Cascade Positive Regulation Of Intracellular Transport Golgi Reassembly Histamine Secretion By Mast Cell Establishment Of Golgi Localization Golgi Inheritance Inflammatory Response Regulation Of Intracellular Transport Histamine Secretion Negative Regulation Of Fibrinolysis Thrombin Receptor Signaling Pathway Histamine Transport Peptidyl-glutamic Acid Carboxylation Regulation Of Fibrinolysis Golgi Localization Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Mast Cell Degranulation Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Mast Cell Mediated Immunity Response To Stress Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Lysosome Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mast Cell Activation Regulation Of Astrocyte Differentiation Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Leukocyte Degranulation	Blood Coagulation, Intrinsic Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Platelet Activation Protein Activation Cascade Regulation Of Blood Coagulation Cell Activation Response To Stress Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Inflammatory Response Regulation Of Fibrinolysis Platelet Degranulation Defense Response Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Response To Stimulus Exocytosis Positive Regulation Of Fibrinolysis Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Secretion By Cell MRNA Transcription From RNA Polymerase II Promoter MRNA Transcription Secretion Negative Regulation Of Platelet Activation Cell Adhesion Regulation Of Ion Homeostasis Cellular Extravasation Fibrinolysis Cytosolic Calcium Ion Homeostasis Leukocyte Migration Positive Regulation Of Intracellular Transport Protein Processing Cellular Localization Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Acute Inflammatory Response Positive Regulation Of Transport Establishment Of Localization In Cell Threonylcarbamoyladenosine Biosynthetic Process
Tagcloud ?		africa alleles arg arginine cervical codon cofactors come controversial determination done exon gabonese genotype genotypes genotyping homozygous hpv hpv16 locus my09 nested papillomavirus polymorphism predominant primers pro proline seem	acantholysis anxa8l1 atp2c1 blistering c5a cd1b cd32 cd88 cdh8 cdh9 chrm3 chrnd chrne col21a1 cyb5b desmoglein dra dsc1 dsc3 justifies mucocutaneous multiplexed ndufs1 pdha1 pemphigus pkp3 pmp22 slc36a4 sod2
Tagcloud (Difference) ?		africa alleles arg arginine cervical codon cofactors come controversial determination done exon gabonese genotype genotypes genotyping homozygous hpv hpv16 locus my09 nested papillomavirus polymorphism predominant primers pro proline seem	acantholysis anxa8l1 atp2c1 blistering c5a cd1b cd32 cd88 cdh8 cdh9 chrm3 chrnd chrne col21a1 cyb5b desmoglein dra dsc1 dsc3 justifies mucocutaneous multiplexed ndufs1 pdha1 pemphigus pkp3 pmp22 slc36a4 sod2
Tagcloud (Intersection) ?