GP5

Description		glycoprotein V platelet
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex
	Molecular Function	Protein Binding
	Biological Process	Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		3 interacting genes: F2 GP1BA YWHAZ
Entrez ID		2814
HPRD ID		01431
Ensembl ID		ENSG00000178732
Uniprot IDs		P40197
PDB IDs
Enriched GO Terms of Interacting Partners?		Thrombin-activated Receptor Signaling Pathway Fibrinolysis Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Regulation Of Platelet Activation Negative Regulation Of Hemostasis Negative Regulation Of Wound Healing Platelet Activation Regulation Of Hemostasis Regulation Of Blood Coagulation Coagulation Blood Coagulation Hemostasis Blood Microparticle Regulation Of Sequestering Of Calcium Ion Regulation Of Wound Healing Regulation Of Protein Localization To Nucleus Regulation Of Response To Wounding Synaptic Target Recognition Thrombospondin Receptor Activity Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Thrombin-activated Receptor Activity Golgi Reassembly Phosphoserine Residue Binding Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway External Side Of Plasma Membrane Blood Coagulation, Intrinsic Pathway Establishment Of Golgi Localization Extracellular Exosome Neutrophil-mediated Killing Of Bacterium Cytolysis By Host Of Symbiont Cells Negative Regulation Of Fibrinolysis Positive Regulation Of Platelet Activation Negative Regulation Of Astrocyte Differentiation Regulation Of Lysosome Organization Golgi Localization Antibacterial Innate Immune Response Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Regulation Of Biological Quality Protein Activation Cascade Neutrophil Mediated Immunity Positive Regulation Of Collagen Biosynthetic Process Megakaryocyte Development Cell Activation Regulation Of Cell Activation Negative Regulation Of Glial Cell Differentiation Positive Regulation Of Blood Coagulation
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