GNL1 and VPS35

Number of citations of the paper that reports this interaction (PubMedID 33305682)
68

Data Source:
BioGRID (unspecified method)

		GNL1	VPS35
Description		G protein nucleolar 1 (putative)	VPS35 retromer complex component
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Postsynaptic Density Membrane Retromer Complex Retromer, Cargo-selective Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Tubular Endosome Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity Structural Molecule Activity GTP Binding	Protein Binding D1 Dopamine Receptor Binding
	Biological Process	T Cell Mediated Immunity DNA Damage Response Signal Transduction	Intracellular Protein Transport Lysosome Organization Positive Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Protein Transport Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Negative Regulation Of Protein Homooligomerization Protein Localization To Organelle Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Regulation Of Protein Catabolic Process Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Voluntary Musculoskeletal Movement Regulation Of Transport Regulation Of Protein Metabolic Process Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Wnt Protein Secretion Regulation Of Synapse Maturation Positive Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Locomotion Involved In Locomotory Behavior Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Postsynapse Organization Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Regulation Of Postsynapse Assembly Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dopamine Biosynthetic Process Negative Regulation Of Protein Localization Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Presynapse Assembly Regulation Of Terminal Button Organization
Pathways			WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Lung cancer ( 28604730) Major depressive disorder ( 27479909) Neuroticism ( 29255261) Rosacea symptom severity ( 29771307) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		5 interacting genes: GDI1 PTP4A1 SIRPA VPS35 ZNF212	15 interacting genes: APP DRD1 FILNC1 GNL1 LINC01554 MTNR1B PRPF19 SLC11A2 SNX1 USP7 VEGFA VPS26B VPS29 YBX1 ZNF512B
Entrez ID		2794	55737
HPRD ID		00879	06085
Ensembl ID		ENSG00000204590	ENSG00000069329
Uniprot IDs		A0A024RCR2 B4DYK6 P36915	Q96QK1
PDB IDs			2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI 7BLN 7BLO 8R02 8R0J 8RKS
Enriched GO Terms of Interacting Partners?		Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Diamide Cellular Response To Sodium Arsenite Vesicle-mediated Transport To The Plasma Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation Of Protein Targeting To Membrane Rab GDP-dissociation Inhibitor Activity Negative Regulation Of Entry Of Bacterium Into Host Cell Neuromuscular Process General Adaptation Syndrome, Behavioral Process Positive Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Protein Homooligomerization Mitochondrion-derived Vesicle Positive Regulation Of Wnt Protein Secretion Regulation Of Locomotion Involved In Locomotory Behavior Tubular Endosome Negative Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Dopamine Metabolic Process Retromer, Cargo-selective Complex Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Voluntary Musculoskeletal Movement Regulation Of Terminal Button Organization Regulation Of Dopamine Biosynthetic Process Mitochondrion To Lysosome Vesicle-mediated Transport Negative Regulation Of Protein Oligomerization Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Protein Binding Involved In Heterotypic Cell-cell Adhesion Cellular Response To Interleukin-12 Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Response To Interleukin-12 Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Monocyte Extravasation Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Entry Of Bacterium Into Host Cell D1 Dopamine Receptor Binding Negative Regulation Of Inflammatory Response Negative Regulation Of Cellular Component Organization Negative Regulation Of Protein Localization Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Protein Antigen Binding Neurotransmitter Receptor Transport To Postsynaptic Membrane Mitochondrial Fragmentation Involved In Apoptotic Process Establishment Of Protein Localization To Postsynaptic Membrane Regulation Of Lysosomal Protein Catabolic Process Regulation Of Dopamine Receptor Signaling Pathway	Negative Regulation Of MiRNA Transcription Retromer Complex Retromer, Cargo-selective Complex Early Endosome Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Retrograde Transport, Endosome To Golgi Mating Behavior Cellular Response To Catecholamine Stimulus Regulation Of Neurotransmitter Uptake Response To Catecholamine Insulin Receptor Binding Cytosolic Transport Positive Regulation Of Receptor Internalization Blood Vessel Diameter Maintenance Regulation Of Tube Size Late Endosome Endosome Chemoattractant Activity Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Early Endosome Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Chemotaxis Regulation Of Protein Localization Nickel Cation Transmembrane Transporter Activity Nickel Cation Transmembrane Transport Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Visual Learning Positive Regulation Of Receptor-mediated Endocytosis Vasodilation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Protein Transport Acetylcholine Receptor Activator Activity Cell Projection Morphogenesis Myeloid Cell Development Visual Behavior Learning Or Memory Platelet Alpha Granule Lumen
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