NMT1 and MARCKS

Number of citations of the paper that reports this interaction (PubMedID 30942445)
77

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)
HPRD (in vitro)

		NMT1	MARCKS
Description		N-myristoyltransferase 1	myristoylated alanine rich protein kinase C substrate
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Nucleoplasm Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Actin Cytoskeleton Membrane Nuclear Speck Cell Junction Actin Filament Bundle Germinal Vesicle Organelle Extracellular Exosome
	Molecular Function	Glycylpeptide N-tetradecanoyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Peptidyl-lysine N6-myristoyltransferase Activity Myristoyltransferase Activity	Actin Binding Protein Kinase C Binding Calmodulin Binding Identical Protein Binding Actin Filament Binding
	Biological Process	In Utero Embryonic Development N-terminal Peptidyl-glycine N-myristoylation Regulation Of Opsin-mediated Signaling Pathway Cellular Response To Nutrient Levels Ketone Metabolic Process Protein Localization To Membrane Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of TORC1 Signaling	Apoptotic Process Mitochondrion Organization Actin Filament Organization Central Nervous System Development Neural Tube Development Neurogenesis Response To Endoplasmic Reticulum Stress Actin Filament Bundle Assembly Actin Crosslink Formation
Pathways		Late Phase of HIV Life Cycle eNOS activation Inactivation, recovery and regulation of the phototransduction cascade Activation, myristolyation of BID and translocation to mitochondria	Acetylcholine regulates insulin secretion
Drugs		(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone
Diseases
GWAS		Asthma ( 31619474) Blood glucose levels ( 31928498) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Multisite chronic pain ( 31194737 33830993) Periventricular white matter hyperintensities ( 32517579) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Systolic blood pressure ( 31928498 30578418) Walking pace ( 33128006) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549)	Alcohol dependence ( 33290381) Bipolar disorder (body mass index interaction) ( 24322204) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Household income ( 31844048) Household income (MTAG) ( 31844048) Type 2 diabetes ( 25760438)
Interacting Genes		14 interacting genes: ANXA13 ARL5A CABP1 CABP2 CAPN2 CSNK2A1 FYN GNAZ HPCA LYN MARCKS NOS3 SRC TP53	11 interacting genes: CALM2 CCNE1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB SPP1 TOB1
Entrez ID		4836	4082
HPRD ID		01187	07519
Ensembl ID		ENSG00000136448	ENSG00000277443
Uniprot IDs		P30419	P29966 Q6NVI1
PDB IDs		1RXT 3IU1 3IU2 3IWE 3JTK 4C2Y 4C2Z 5MU6 5NPQ 5O6H 5O6J 5O9S 5O9T 5O9U 5O9V 5UUT 6EHJ 6F56 6FZ2 6FZ3 6FZ5 6PAV 6QRM 6SJZ 6SK2 6SK3 6SK8 6SKJ 7OWM 7OWN 7OWO 7OWP 7OWQ 7OWR 7OWU 7RK3 8Q23 8Q24 8Q26 8Q2Z 8Q3D 8Q3S 8Q3T
Enriched GO Terms of Interacting Partners?		Membrane Raft Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Scaffold Protein Binding Cellular Response To Lectin Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Binding Regulation Of Cellular Localization Response To Amino Acid Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway Regulation Of Protein Localization Response To Fluid Shear Stress Non-membrane Spanning Protein Tyrosine Kinase Activity T Cell Costimulation Regulation Of Transport Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Apoptotic Signaling Pathway Enzyme Binding Fc Receptor Signaling Pathway Signaling Receptor Activator Activity Cellular Response To L-glutamate Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Phospholipase Activator Activity Cellular Response To Amino Acid Stimulus Cellular Response To Oxygen-containing Compound Positive Regulation Of Protein Localization To Membrane Regulation Of Establishment Of Protein Localization Regulation Of Apoptotic Process Plasma Membrane Regulation Of Programmed Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Hydrogen Peroxide DNA Damage Checkpoint Signaling Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cytoplasm Negative Regulation Of Cell Communication Negative Regulation Of Signaling Autophagy Calcium Ion Binding Perinuclear Endoplasmic Reticulum Cellular Response To Stress Response To L-glutamate Lymphocyte Proliferation Mononuclear Cell Proliferation Negative Regulation Of Protein Transport Phospholipase Binding Cellular Response To Platelet-derived Growth Factor Stimulus	Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Kinase Activity Cyclin E1-CDK2 Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Phosphorylation Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Protein Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Nuclear Membrane Disassembly Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Bone Resorption Nuclear Membrane Disassembly Membrane Disassembly Calyx Of Held Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Hormone Secretion Decidualization Nuclear Androgen Receptor Binding Presynaptic Cytosol Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Regulation Of Mitotic Cell Cycle Protein Modification Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Hormone Levels Regulation Of Bone Resorption Regulation Of Cell Cycle Transferase Activity Response To Ketone Regulation Of Bone Remodeling Calcium Channel Regulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase C Binding Nuclear Membrane Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Hormone Secretion Chromatin Remodeling Cell Cycle G2/M Phase Transition Myristoyltransferase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
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