TOR1B and MRPS2

Data Source: HiPPIP (Novel)

		TOR1B	MRPS2
Name		torsin family 1 member B	mitochondrial ribosomal protein S2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Membrane Nuclear Membrane Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Small Ribosomal Subunit Ribosome Small Ribosomal Subunit Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Identical Protein Binding	Structural Constituent Of Ribosome
	Biological Process	Response To Unfolded Protein Endoplasmic Reticulum Organization Protein Localization To Nucleus Nuclear Membrane Organization	Translation Mitochondrial Translation Mitochondrial Ribosome Assembly
Pathways		Cargo recognition for clathrin-mediated endocytosis	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial protein degradation Mitochondrial ribosome-associated quality control
GWAS		Alanine aminotransferase levels ( 33547301 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Percent liver fat ( 34128465 )	No GWAS studies recorded
Novel Interactors		3 novel interactors: KCNJ15 MRPS2 NFATC3	3 novel interactors: OBP2A SLC34A3 TOR1B
Interacting Genes		2 interacting genes: CFTR TOR1A	2 interacting genes: APP UBC
Entrez ID		27348	51116
HPRD ID		16270	14783
Ensembl ID		ENSG00000136816	ENSG00000122140
Uniprot IDs		O14657	Q9Y399
PDB IDs		Not available	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
GO Terms Enriched among Interactors		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding DN4 Thymocyte Differentiation Bicarbonate Transmembrane Transporter Activity Response To Endoplasmic Reticulum Stress Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Artery Morphogenesis Mitochondrial Ribosome Assembly Amelogenesis Regulation Of Artery Morphogenesis Regulation Of Monoatomic Ion Transmembrane Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Deneddylation Positive Thymic T Cell Selection Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Cellular Response To Forskolin ATP Hydrolysis Activity Golgi-associated Vesicle Membrane Synaptic Vesicle Membrane Organization Positive T Cell Selection Response To Forskolin Misfolded Protein Binding Chloride Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transport Sperm Capacitation Regulation Of Neurotransmitter Uptake Calcineurin-NFAT Signaling Cascade Ribosome Assembly Thymic T Cell Selection Negative Regulation Of Smooth Muscle Cell Differentiation Organelle Localization Regulation Of Transport Bicarbonate Transport Regulation Of Synaptic Vesicle Endocytosis Nuclear Envelope Organization	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chemical Homeostasis Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Vesicle Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Sodium-dependent Phosphate Transport Peptidase Activator Activity Cellular Response To Manganese Ion Intracellular Phosphate Ion Homeostasis Endoplasmic Reticulum Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Homeostatic Process