TOR1B and KCNJ15

		TOR1B	KCNJ15
Description		torsin family 1 member B	potassium inwardly rectifying channel subfamily J member 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Membrane Nuclear Membrane Extracellular Exosome	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Identical Protein Binding	Inward Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Response To Unfolded Protein Endoplasmic Reticulum Organization Protein Localization To Nucleus Nuclear Membrane Organization	Monoatomic Ion Transport Potassium Ion Transport Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Cargo recognition for clathrin-mediated endocytosis	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ritodrine Yohimbine Butamben
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514) Percent liver fat ( 34128465)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Monocyte count ( 32888494) Non-response to antidepressants and depression ( 27622933) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: CFTR TOR1A	6 interacting genes: IL16 KCNJ16 KCNJ2 KCNJ5 PATJ SNTA1
Entrez ID		27348	3772
HPRD ID		16270	03659
Ensembl ID		ENSG00000136816	ENSG00000157551
Uniprot IDs		O14657	Q99712
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding DN4 Thymocyte Differentiation Bicarbonate Transmembrane Transporter Activity Response To Endoplasmic Reticulum Stress Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Artery Morphogenesis Mitochondrial Ribosome Assembly Amelogenesis Regulation Of Artery Morphogenesis Regulation Of Monoatomic Ion Transmembrane Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Deneddylation Positive Thymic T Cell Selection Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Cellular Response To Forskolin ATP Hydrolysis Activity Golgi-associated Vesicle Membrane Synaptic Vesicle Membrane Organization Positive T Cell Selection Response To Forskolin Misfolded Protein Binding Chloride Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transport Sperm Capacitation Regulation Of Neurotransmitter Uptake Calcineurin-NFAT Signaling Cascade Ribosome Assembly Thymic T Cell Selection Negative Regulation Of Smooth Muscle Cell Differentiation Organelle Localization Regulation Of Transport Bicarbonate Transport Regulation Of Synaptic Vesicle Endocytosis Nuclear Envelope Organization	Regulation Of Monoatomic Ion Transport Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Inward Rectifier Potassium Channel Activity Membrane Repolarization Regulation Of Heart Rate Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Ion Channel Complex Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Cardiac Conduction Potassium Ion Transport Regulation Of Heart Contraction Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Blood Circulation Inorganic Cation Import Across Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Action Potential Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Metal Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Import Across Plasma Membrane Positive Regulation Of Potassium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Kinesin Binding Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Ammon Gyrus Development Dendrite Morphogenesis Monoatomic Ion Transport Regulation Of System Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Potassium Ion Transmembrane Transport Vestibular Nucleus Development Regulation Of Monoatomic Cation Transmembrane Transport Relaxation Of Skeletal Muscle
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