TOR1B and NFATC3

		TOR1B	NFATC3
Description		torsin family 1 member B	nuclear factor of activated T cells 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Membrane Nuclear Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Unfolded Protein Endoplasmic Reticulum Organization Protein Localization To Nucleus Nuclear Membrane Organization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Calcineurin-NFAT Signaling Cascade Positive Thymic T Cell Selection Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription DN4 Thymocyte Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Artery Morphogenesis
Pathways		Cargo recognition for clathrin-mediated endocytosis	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514) Percent liver fat ( 34128465)	Chronotype ( 30696823) Estimated glomerular filtration rate ( 31015462) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: CFTR TOR1A	7 interacting genes: CDK6 CSNK1A1 FOS IGF2BP3 MAPK8 MAPK9 TTF1
Entrez ID		27348	4775
HPRD ID		16270	04077
Ensembl ID		ENSG00000136816	ENSG00000072736
Uniprot IDs		O14657	B5B2S0 B5B2S1 Q12968
PDB IDs			2XRW 2XS0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding DN4 Thymocyte Differentiation Bicarbonate Transmembrane Transporter Activity Response To Endoplasmic Reticulum Stress Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Artery Morphogenesis Mitochondrial Ribosome Assembly Amelogenesis Regulation Of Artery Morphogenesis Regulation Of Monoatomic Ion Transmembrane Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Deneddylation Positive Thymic T Cell Selection Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Cellular Response To Forskolin ATP Hydrolysis Activity Golgi-associated Vesicle Membrane Synaptic Vesicle Membrane Organization Positive T Cell Selection Response To Forskolin Misfolded Protein Binding Chloride Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transport Sperm Capacitation Regulation Of Neurotransmitter Uptake Calcineurin-NFAT Signaling Cascade Ribosome Assembly Thymic T Cell Selection Negative Regulation Of Smooth Muscle Cell Differentiation Organelle Localization Regulation Of Transport Bicarbonate Transport Regulation Of Synaptic Vesicle Endocytosis Nuclear Envelope Organization	JUN Kinase Activity Parallel Fiber To Purkinje Cell Synapse Protein Serine Kinase Activity NLRP3 Inflammasome Complex Assembly Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway MAP Kinase Activity Protein Serine/threonine Kinase Activity R-SMAD Binding Response To Reactive Oxygen Species Positive Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Protein Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Oxidative Stress Regulation Of MRNA Stability Regulation Of RNA Stability Cyclin D2-CDK6 Complex Medium-term Memory Cellular Response To Prolactin JUN Phosphorylation Positive Regulation Of MiRNA Transcription Fc Receptor Signaling Pathway Cellular Response To Nutrient Levels JNK Cascade Kinase Activity Positive Regulation Of MiRNA Metabolic Process Cellular Response To Chemical Stress Cellular Senescence Dendriole Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding I(KACh) Inward Rectifier Potassium Channel Complex Protein Localization To Tricellular Tight Junction Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of MiRNA Transcription Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Neural Plate Anterior/posterior Regionalization Response To Prolactin Conditioned Taste Aversion Regulation Of MiRNA Metabolic Process Regulation Of MRNA Metabolic Process Termination Of RNA Polymerase I Transcription Regulation Of Cell Growth By Extracellular Stimulus Protein Phosphorylation
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