TOR1B and TOR1A

Number of citations of the paper that reports this interaction (PubMedID 15147511)
0

Data Source:
HPRD (in vitro)

		TOR1B	TOR1A
Description		torsin family 1 member B	torsin family 1 member A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Membrane Nuclear Membrane Extracellular Exosome	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Synaptic Vesicle Endomembrane System Membrane Transport Vesicle Secretory Granule Growth Cone Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Cell Projection Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Identical Protein Binding	Nucleotide Binding Protein Binding ATP Binding Cytoskeletal Protein Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Identical Protein Binding Unfolded Protein Binding Misfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Response To Unfolded Protein Endoplasmic Reticulum Organization Protein Localization To Nucleus Nuclear Membrane Organization	Protein Deneddylation Protein Folding Response To Oxidative Stress Nuclear Envelope Organization Cell Adhesion Neuron Projection Development Protein Localization To Nucleus ERAD Pathway Wound Healing, Spreading Of Cells Intermediate Filament Cytoskeleton Organization Synaptic Vesicle Transport Synaptic Vesicle Membrane Organization Regulation Of Dopamine Uptake Involved In Synaptic Transmission Nuclear Membrane Organization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Protein Localization To Cell Surface
Pathways		Cargo recognition for clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514) Percent liver fat ( 34128465)	Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Prostate cancer (early onset) ( 29892016)
Interacting Genes		2 interacting genes: CFTR TOR1A	7 interacting genes: KRTAP10-7 LMNA LRRC7 MDFI SNCA TOR1AIP2 TOR1B
Entrez ID		27348	1861
HPRD ID		16270	06897
Ensembl ID		ENSG00000136816	ENSG00000136827
Uniprot IDs		O14657	B3KPA1 O14656
PDB IDs			5J1S 5J1T 6OIF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding DN4 Thymocyte Differentiation Bicarbonate Transmembrane Transporter Activity Response To Endoplasmic Reticulum Stress Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Artery Morphogenesis Mitochondrial Ribosome Assembly Amelogenesis Regulation Of Artery Morphogenesis Regulation Of Monoatomic Ion Transmembrane Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Deneddylation Positive Thymic T Cell Selection Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Cellular Response To Forskolin ATP Hydrolysis Activity Golgi-associated Vesicle Membrane Synaptic Vesicle Membrane Organization Positive T Cell Selection Response To Forskolin Misfolded Protein Binding Chloride Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transport Sperm Capacitation Regulation Of Neurotransmitter Uptake Calcineurin-NFAT Signaling Cascade Ribosome Assembly Thymic T Cell Selection Negative Regulation Of Smooth Muscle Cell Differentiation Organelle Localization Regulation Of Transport Bicarbonate Transport Regulation Of Synaptic Vesicle Endocytosis Nuclear Envelope Organization	Protein Localization To Nucleus Protein Localization To Nuclear Envelope Membrane Organization Protein Localization To Organelle Negative Regulation Of Muscle Hypertrophy Cardiac Cell Development Nuclear Membrane Identical Protein Binding Negative Regulation Of Cardiac Muscle Hypertrophy Protein Sequestering Activity Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Negative Regulation Of Exocytosis Coronary Sinus Valve Morphogenesis Enzyme Inhibitor Activity Foregut Morphogenesis Negative Regulation Of Sperm Capacitation Alkylglycerophosphoethanolamine Phosphodiesterase Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Kinesin Binding Endoplasmic Reticulum Organization Protein-containing Complex Localization DNA Double-strand Break Attachment To Nuclear Envelope Regulation Of Cardiac Muscle Hypertrophy Structural Constituent Of Nuclear Lamina Axis Specification Notch Signaling Involved In Heart Development Endocardium Morphogenesis Mitral Valve Formation Positive Regulation Of Aorta Morphogenesis Coronary Vein Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Right Atrium Morphogenesis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Muscle Cell Development Intracellular Protein Localization Regulation Of Locomotion Import Into Nucleus Protein Import Into Nucleus MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
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