TOR1B

Description		torsin family 1 member B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Membrane Nuclear Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Identical Protein Binding
	Biological Process	Response To Unfolded Protein Endoplasmic Reticulum Organization Protein Localization To Nucleus Nuclear Membrane Organization
Pathways		Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514) Percent liver fat ( 34128465)
Novel Interacting Genes		3 novel interacting genes: KCNJ15 MRPS2 NFATC3
Interacting Genes		2 interacting genes: CFTR TOR1A
Entrez ID		27348
HPRD ID		16270
Ensembl ID		ENSG00000136816
Uniprot IDs		O14657
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding DN4 Thymocyte Differentiation Bicarbonate Transmembrane Transporter Activity Response To Endoplasmic Reticulum Stress Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Artery Morphogenesis Mitochondrial Ribosome Assembly Amelogenesis Regulation Of Artery Morphogenesis Regulation Of Monoatomic Ion Transmembrane Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Deneddylation Positive Thymic T Cell Selection Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Cellular Response To Forskolin ATP Hydrolysis Activity Golgi-associated Vesicle Membrane Synaptic Vesicle Membrane Organization Positive T Cell Selection Response To Forskolin Misfolded Protein Binding Chloride Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transport Sperm Capacitation Regulation Of Neurotransmitter Uptake Calcineurin-NFAT Signaling Cascade Ribosome Assembly Thymic T Cell Selection Negative Regulation Of Smooth Muscle Cell Differentiation Organelle Localization Regulation Of Transport Bicarbonate Transport Regulation Of Synaptic Vesicle Endocytosis Nuclear Envelope Organization
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