POLL and FSD2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		POLL	FSD2
Description		DNA polymerase lambda	fibronectin type III and SPRY domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Site Of Double-strand Break	Nucleus Cytoplasm Sarcoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Lyase Activity DNA Polymerase Activity Metal Ion Binding 5'-deoxyribose-5-phosphate Lyase Activity	Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes DNA Biosynthetic Process
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS			HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Tourette syndrome ( 30818990)
Interacting Genes		42 interacting genes: APP ATM CCNDBP1 CDK1 CDK2 CMTM5 FAM9B FSD2 GOLGA6L9 HMBOX1 HUWE1 KRT16 KRT19 KRT27 KRT40 KRTAP10-3 KRTAP10-7 LCN2 LDOC1 MAGEA12 MAGEA2 MAGEA2B MAL2 MCC MDFI PCNA PICK1 PNMA1 PRKD3 REV1 RPA1 SSX2IP TFCP2 TFIP11 TNFRSF10D TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H ZRANB1	93 interacting genes: AQP1 ARFIP2 ATF7IP2 ATG14 ATXN7L2 BEX2 BEX3 BRD8 C1orf216 CAMSAP3 CBX8 CCDC112 CCDC120 CCDC146 CCDC187 CCHCR1 CDC73 CDK18 CORO1A CTAG1A CTAG1B CWF19L2 DCX DTNB ENKD1 EXOC3 FAM107A FAM110A FAM161A FAM50B FAM90A1 FARS2 FMR1 HDAC4 HGS IFT20 KANSL1 KLHL40 LATS1 LENG1 LNX1 MCRS1 MID2 MRPL11 MYBPC2 NDN OIP5 OXNAD1 PBX3 PIK3R3 PNMA5 POLL PPP1R18 PPP2R5D PRPF18 PRPF31 PSMB4 RCOR3 RNF8 SCNM1 SH2D4A SMARCE1 SNAPIN SPATC1L TCEANC THAP7 TLE5 TSGA10IP TTC23 UBTFL1 VEZF1 ZBTB38 ZC2HC1C ZMAT2 ZNF124 ZNF20 ZNF230 ZNF35 ZNF408 ZNF410 ZNF417 ZNF490 ZNF572 ZNF580 ZNF581 ZNF587 ZNF648 ZNF76 ZNF774 ZNF777 ZNF835 ZNF837 ZSCAN26
Entrez ID		27343	123722
HPRD ID		09394	17291
Ensembl ID		ENSG00000166169	ENSG00000186628
Uniprot IDs		A8K860 B4DE17 Q5JQP8 Q9UGP5	A1L4K1 B7ZM05
PDB IDs		1NZP 1RZT 1XSL 1XSN 1XSP 2BCQ 2BCR 2BCS 2BCU 2BCV 2GWS 2JW5 2PFN 2PFO 2PFP 2PFQ 3C5F 3C5G 3HW8 3HWT 3HX0 3MDA 3MDC 3MGH 3MGI 3PML 3PMN 3PNC 3UPQ 3UQ0 3UQ2 4FO6 4K4G 4K4H 4K4I 4X5V 4XA5 4XQ8 4XRH 4XUS 5CA7 5CB1 5CHG 5CJ7 5CP2 5CR0 5CWR 5DDM 5DDY 5DKW 5III 5IIJ 5IIK 5IIL 5IIM 5IIN 5IIO 5W4G 7M07 7M08 7M09 7M0A 7M0B 7M0C 7M0D 7M0E 7M43 7M44 7M45 7M46 7M47 7M48 7M49 7M4A 7M4B 7M4C 7M4D 7M4E 7M4F 7M4G 7M4H 7M4I 7M4J 7M4K 7M4L 7UN7 8U0O
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Telomere Maintenance Chromosome, Telomeric Region Keratin Filament Protein K48-linked Ubiquitination Telomere Organization Ubiquitin-protein Transferase Activity DNA Biosynthetic Process Intermediate Filament Post-translational Protein Modification Protein Polyubiquitination Nucleus DNA Metabolic Process Protein Monoubiquitination Structural Constituent Of Skin Epidermis Cellular Senescence Cyclin-dependent Protein Kinase Activity Chromosome Organization DNA Repair DNA Replication Intermediate Filament Organization Protein Localization To Site Of Double-strand Break Negative Regulation Of Protein Acetylation Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Histone Kinase Activity Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process DNA Damage Response Protein Ubiquitination Protection From Non-homologous End Joining At Telomere Cellular Response To Reactive Oxygen Species Positive Regulation Of DNA Replication Positive Regulation Of Protein Ubiquitination PML Body Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Cellular Response To X-ray Negative Regulation Of Protein Sumoylation Male Germ Cell Nucleus Positive Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Epithelial Cell Differentiation Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Binding DNA Strand Resection Involved In Replication Fork Processing Telomere Maintenance In Response To DNA Damage	Zinc Ion Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Regulation Of Metabolic Process Centriole Microtubule Anchoring Microtubule Binding
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