TNRC6A and CNOT7

Number of citations of the paper that reports this interaction (PMID 21984185)
56

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TNRC6A	CNOT7
Gene Name		trinucleotide repeat containing 6A	CCR4-NOT transcription complex, subunit 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleoplasm Cytosol Micro-ribonucleoprotein Complex	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane CCR4-NOT Complex
	Molecular Function	Nucleotide Binding Protein Binding Poly(A) RNA Binding	3'-5'-exoribonuclease Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Signal Transducer Activity Protein Binding Metal Ion Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Starvation Gene Expression Posttranscriptional Gene Silencing Gene Silencing By MiRNA Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Carbohydrate Metabolic Process Transcription, DNA-templated Regulation Of Translation Signal Transduction Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Gene Expression Gene Silencing By RNA Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Transcriptional regulation by small RNAs Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Protein-Protein Interactions		7 interactors: AGO4 CNOT6L CNOT7 PAN2 TRIM65 TRIP13 WNK1	16 interactors: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FOXC2 HOXD4 IKBKG PABPC1 TNRC6A TOB1 TOB2
Entrez ID		27327	29883
HPRD ID		11640	05370
Ensembl ID		ENSG00000090905	ENSG00000198791
Uniprot IDs		Q8NDV7	Q9UIV1
PDB IDs			2D5R 4GMJ
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Translation Gene Silencing By MiRNA Posttranscriptional Gene Silencing Nucleic Acid Phosphodiester Bond Hydrolysis MRNA Processing Posttranscriptional Regulation Of Gene Expression RNA Metabolic Process RNA Processing Gene Expression Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nucleobase-containing Compound Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Destabilization Cytoplasmic MRNA Processing Body Assembly Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Destabilization Negative Regulation Of Gene Expression Positive Regulation Of Systemic Arterial Blood Pressure Nitrogen Compound Metabolic Process Female Meiosis I Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Positive Regulation Of MRNA Catabolic Process Synaptonemal Complex Assembly Cellular Metabolic Process	Regulation Of Translation Regulation Of Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA 3'-end Processing Regulation Of MRNA 3'-end Processing Regulation Of Protein Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Gene Silencing By RNA Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle MRNA 3'-end Processing Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Translation Regulation Of MRNA Processing Positive Regulation Of Cell Cycle Regulation Of Cell Differentiation Gene Silencing Regulation Of Nitrogen Compound Metabolic Process RNA 3'-end Processing Positive Regulation Of Mitotic Cell Cycle Dentate Gyrus Development Negative Regulation Of Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Gene Expression Positive Regulation Of Cell Proliferation Cell Division MRNA Polyadenylation Regulation Of Apoptotic Process Gene Silencing By MiRNA RNA Polyadenylation
Tagcloud ?		arrest bim cdkn1a cdkn1c clusters derepressed derepression disruption endoderm gt gw182 lats1 lats2 microrna mirna mirnas p21 p27 proper pten rb1 rbl sac selectively silencing suppression targets yolk	actr1a backgrounds bbs2 bovines c2orf29 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Difference) ?		arrest bim cdkn1a cdkn1c clusters derepressed derepression disruption endoderm gt gw182 lats1 lats2 microrna mirna mirnas p21 p27 proper pten rb1 rbl sac selectively silencing suppression targets yolk	actr1a backgrounds bbs2 bovines c2orf29 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Intersection) ?