TNRC6A and TRIM65

Number of citations of the paper that reports this interaction (PMID 24778252)
0

Data Source:
BioGRID (enzymatic study)

		TNRC6A	TRIM65
Gene Name		trinucleotide repeat containing 6A	tripartite motif containing 65
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleoplasm Cytosol Micro-ribonucleoprotein Complex	Intracellular
	Molecular Function	Nucleotide Binding Protein Binding Poly(A) RNA Binding	Zinc Ion Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Starvation Gene Expression Posttranscriptional Gene Silencing Gene Silencing By MiRNA Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Transcriptional regulation by small RNAs Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	White matter hyperintensity burden ( 21681796)
Protein-Protein Interactions		7 interactors: AGO4 CNOT6L CNOT7 PAN2 TRIM65 TRIP13 WNK1	9 interactors: ANAPC11 MARCH7 MKRN3 RBCK1 SRPK1 TNRC6A UBE2U UBE2Z UBE3A
Entrez ID		27327	201292
HPRD ID		11640	15569
Ensembl ID		ENSG00000090905	ENSG00000141569
Uniprot IDs		Q8NDV7	Q6PJ69
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Translation Gene Silencing By MiRNA Posttranscriptional Gene Silencing Nucleic Acid Phosphodiester Bond Hydrolysis MRNA Processing Posttranscriptional Regulation Of Gene Expression RNA Metabolic Process RNA Processing Gene Expression Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nucleobase-containing Compound Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Destabilization Cytoplasmic MRNA Processing Body Assembly Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Destabilization Negative Regulation Of Gene Expression Positive Regulation Of Systemic Arterial Blood Pressure Nitrogen Compound Metabolic Process Female Meiosis I Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Positive Regulation Of MRNA Catabolic Process Synaptonemal Complex Assembly Cellular Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Sperm Entry Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Linear Polyubiquitination Proteolysis Regulation Of Protein Ubiquitination Catabolic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Sperm Chromatin Condensation Negative Regulation Of Necroptotic Process Negative Regulation Of Necrotic Cell Death Cellular Metabolic Process Regulation Of Necroptotic Process
Tagcloud ?		arrest bim cdkn1a cdkn1c clusters derepressed derepression disruption endoderm gt gw182 lats1 lats2 microrna mirna mirnas p21 p27 proper pten rb1 rbl sac selectively silencing suppression targets yolk
Tagcloud (Difference) ?		arrest bim cdkn1a cdkn1c clusters derepressed derepression disruption endoderm gt gw182 lats1 lats2 microrna mirna mirnas p21 p27 proper pten rb1 rbl sac selectively silencing suppression targets yolk
Tagcloud (Intersection) ?