TNRC6A

Description		trinucleotide repeat containing adaptor 6A
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GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Golgi Apparatus Cytosol RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Regulation Of Translation Endoderm Development Cellular Response To Starvation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Metabolic syndrome ( 31589552) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418 27618448 27841878) Smoking initiation ( 33082346) Systolic blood pressure ( 27841878 27618448 30578418) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: DMRTB1 PAN2 QKI RBFOX2 SMARCB1 TRIM65 TRIP13 TXNL4A UBC WNK1
Entrez ID		27327
HPRD ID		11640
Ensembl ID		ENSG00000090905
Uniprot IDs		Q8NDV7
PDB IDs		5W6V 7RUP
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Macromolecule Metabolic Process MRNA Processing
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