TOX3 and GCM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TOX3	GCM2
Description		TOX high mobility group box family member 3	glial cells missing transcription factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Nucleus
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Chromatin DNA Binding Protein Homodimerization Activity Phosphoprotein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Intracellular Phosphate Ion Homeostasis Gliogenesis Positive Regulation Of Transcription By RNA Polymerase II Parathyroid Gland Development
Pathways
Drugs
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Brain morphology (MOSTest) ( 32665545) Brain volume in infants (grey matter) ( 28763065) BRCA1 mutation in breast cancer ( 33597508) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 19330030 20585626 31757997 20453838 29059683 21263130 20872241 27117709 25956309 25327703 23535729 24143190 23535733) Breast cancer (early onset) ( 24493630) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (male) ( 23001122) Breast cancer in BRCA2 mutation carriers ( 23544012) Chronotype ( 30696823) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Gut microbiota (bacterial taxa) ( 27723756) Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 27479909) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Parkinson's disease ( 28892059) Polycystic ovary syndrome ( 30566500 22885925) Response to tofacitinib treatment (herpes zoster) ( 33455090) Response to tofacitinib treatment (herpes zoster)(time to event) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event) ( 33455090) Restless legs syndrome ( 29029846 21779176)	Menarche and menopause (age at onset) ( 19448621) Metabolite levels ( 23823483) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		12 interacting genes: DUSP21 FHL2 GCM2 IST1 KRTAP9-3 KRTAP9-8 NUP62CL PIN1 POM121 SEZ6L2 TLE5 TSTD2	34 interacting genes: CEACAM6 CRX DOK3 ECM1 FHL3 GPSM1 GSC2 HOXA1 HSF2BP HSFY1 HSFY2 JMJD7 KRTAP6-2 KRTAP7-1 KRTAP8-1 LASP1 LHX3 MEOX2 MYOZ3 PAX6 PAX8 PLEKHG4 POU6F2 RBPMS RUSC1 SSBP1 TBX19 TOX3 TRAF1 USP54 WWOX YPEL3 ZMIZ2 ZNF34
Entrez ID		27324	9247
HPRD ID		19073	04758
Ensembl ID		ENSG00000103460	ENSG00000124827
Uniprot IDs		O15405	O75603
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Nuclear Pore	DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process DNA Binding Sequence-specific DNA Binding Pituitary Gland Development Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Inner Ear Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Fate Specification Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process SMAD Protein Signal Transduction
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