TOX3 and SEZ6L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TOX3	SEZ6L2
Description		TOX high mobility group box family member 3	seizure related 6 homolog like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Neuronal Cell Body
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Chromatin DNA Binding Protein Homodimerization Activity Phosphoprotein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Adult Locomotory Behavior Cerebellar Purkinje Cell Layer Development Synapse Maturation
Pathways
Drugs
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Brain morphology (MOSTest) ( 32665545) Brain volume in infants (grey matter) ( 28763065) BRCA1 mutation in breast cancer ( 33597508) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 19330030 20585626 31757997 20453838 29059683 21263130 20872241 27117709 25956309 25327703 23535729 24143190 23535733) Breast cancer (early onset) ( 24493630) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (male) ( 23001122) Breast cancer in BRCA2 mutation carriers ( 23544012) Chronotype ( 30696823) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Gut microbiota (bacterial taxa) ( 27723756) Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 27479909) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Parkinson's disease ( 28892059) Polycystic ovary syndrome ( 30566500 22885925) Response to tofacitinib treatment (herpes zoster) ( 33455090) Response to tofacitinib treatment (herpes zoster)(time to event) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event) ( 33455090) Restless legs syndrome ( 29029846 21779176)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Anthropometric traits ( 19260139) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Body fat distribution (arm fat ratio) ( 30664634) Response to taxane treatment (paclitaxel) ( 23006423) Schizophrenia ( 25056061 28991256 29483656) Systemic lupus erythematosus ( 23273568)
Interacting Genes		12 interacting genes: DUSP21 FHL2 GCM2 IST1 KRTAP9-3 KRTAP9-8 NUP62CL PIN1 POM121 SEZ6L2 TLE5 TSTD2	7 interacting genes: ETV5 FOXA1 MTDH OASL TK1 TOX3 UNG
Entrez ID		27324	26470
HPRD ID		19073	06686
Ensembl ID		ENSG00000103460	ENSG00000174938
Uniprot IDs		O15405	A0A087WYL5 A0A0A8K8P7 B7Z5L4 Q6UXD5
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Nuclear Pore	Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Neuron Differentiation Nucleus Male Germ-line Stem Cell Asymmetric Division Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Respiratory Basal Cell Differentiation Alveolar Secondary Septum Development Fibrillar Center Positive Regulation Of DNA-binding Transcription Factor Activity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Positive Regulation Of Dopaminergic Neuron Differentiation Epithelial Cell Maturation Involved In Prostate Gland Development Prostate Gland Stromal Morphogenesis Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development DNA Synthesis Involved In Mitotic DNA Replication Thymidine Biosynthetic Process Pyrimidine-containing Compound Metabolic Process Thymidine Kinase Activity Base-excision Repair, AP Site Formation Via Deaminated Base Removal Uracil DNA N-glycosylase Activity Double-stranded RNA Binding 2'-5'-oligoadenylate Synthetase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neuron Differentiation Regulation Of DNA-binding Transcription Factor Activity Intercellular Canaliculus Thymidine Metabolic Process Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Positive Regulation Of RNA Metabolic Process Depyrimidination Interleukin-27-mediated Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Mesenchymal-epithelial Cell Signaling Epithelial Cell Differentiation Involved In Prostate Gland Development Deoxyribonucleoside Monophosphate Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Single Strand Break Repair Negative Regulation Of Programmed Cell Death Positive Regulation Of RIG-I Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Asymmetric Cell Division Dorsal/ventral Neural Tube Patterning Pyrimidine Nucleoside Metabolic Process
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