TOX3 and NUP62CL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TOX3	NUP62CL
Description		TOX high mobility group box family member 3	nucleoporin 62 C-terminal like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nuclear Envelope Nuclear Pore
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Chromatin DNA Binding Protein Homodimerization Activity Phosphoprotein Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Nucleocytoplasmic Transport Protein Transport
Pathways
Drugs
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Brain morphology (MOSTest) ( 32665545) Brain volume in infants (grey matter) ( 28763065) BRCA1 mutation in breast cancer ( 33597508) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 19330030 20585626 31757997 20453838 29059683 21263130 20872241 27117709 25956309 25327703 23535729 24143190 23535733) Breast cancer (early onset) ( 24493630) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (male) ( 23001122) Breast cancer in BRCA2 mutation carriers ( 23544012) Chronotype ( 30696823) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Gut microbiota (bacterial taxa) ( 27723756) Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 27479909) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Parkinson's disease ( 28892059) Polycystic ovary syndrome ( 30566500 22885925) Response to tofacitinib treatment (herpes zoster) ( 33455090) Response to tofacitinib treatment (herpes zoster)(time to event) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event) ( 33455090) Restless legs syndrome ( 29029846 21779176)	Alcoholic chronic pancreatitis ( 28754779)
Interacting Genes		12 interacting genes: DUSP21 FHL2 GCM2 IST1 KRTAP9-3 KRTAP9-8 NUP62CL PIN1 POM121 SEZ6L2 TLE5 TSTD2	8 interacting genes: AGR2 APP DVL2 OGT POU6F2 SNAPIN TOX3 WASHC1
Entrez ID		27324	54830
HPRD ID		19073	06527
Ensembl ID		ENSG00000103460	ENSG00000198088
Uniprot IDs		O15405	A0A0S2Z5E8 Q9H1M0
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Nuclear Pore	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Cytoplasmic Vesicle Frizzled Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Late Endosome To Lysosome Transport Regulation Of ATP Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Positive Regulation Of JNK Cascade Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Intracellular Signal Transduction Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Convergent Extension Involved In Neural Plate Elongation Chromatin DNA Binding Regulation Of Cellular Localization Protein O-acetylglucosaminyltransferase Activity Lung Goblet Cell Differentiation Secretion Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synapse Assembly Regulation Of Spontaneous Synaptic Transmission Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Axon Midline Choice Point Recognition Recycling Endosome NMDA Selective Glutamate Receptor Signaling Pathway
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