GCLC and CCL22

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		GCLC	CCL22
Name		glutamate-cysteine ligase catalytic subunit	C-C motif chemokine ligand 22
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Glutamate-cysteine Ligase Complex	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Glutamate-cysteine Ligase Activity Protein Binding ATP Binding Glutamate Binding Ligase Activity ADP Binding Protein-containing Complex Binding	Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Response To Nutrient Response To Heat Response To Xenobiotic Stimulus Response To Hormone Response To Activity L-ascorbic Acid Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Cell Redox Homeostasis Negative Regulation Of DNA-templated Transcription Response To Arsenic-containing Substance Response To Cadmium Ion Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Blood Vessel Diameter Maintenance Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Hepatic Stellate Cell Activation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Glutathione synthesis and recycling Defective GCLC causes HAGGSD NFE2L2 regulating anti-oxidant/detoxification enzymes	Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs		Glutamic acid Cysteine	None
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency	None
GWAS		Benign prostatic hyperplasia ( 30988330 ) Birth weight ( 31043758 ) Daytime sleep phenotypes ( 27126917 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Waist circumference ( 28552196 )	Asthma ( 32296059 ) Blood protein levels ( 30072576 ) Multiple sclerosis ( 24076602 ) Systemic lupus erythematosus ( 28714469 33272962 )
Novel Interactors		None recorded	1 novel interactors: NLGN4X
Interacting Genes		1 interacting genes: CCL22	10 interacting genes: AQP6 CCL14 CCL19 CCR4 CRYAB DPP4 GCLC HERC3 PF4V1 VCAM1
Entrez ID		2729	6367
HPRD ID		06032	04263
Ensembl ID		ENSG00000001084	ENSG00000102962
Uniprot IDs		E1CEI4 P48506 Q14TF0	O00626
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Eosinophil Migration Eosinophil Chemotaxis CCR Chemokine Receptor Binding Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Granulocyte Migration Myeloid Leukocyte Migration Chemokine Activity Killing Of Cells Of Another Organism Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Antimicrobial Humoral Response Cell Killing Cell Chemotaxis Cytokine Activity Leukocyte Migration Humoral Immune Response	Chemotaxis Locomotion Cell Chemotaxis Chemokine Activity Cell Migration Inflammatory Response Chemokine-mediated Signaling Pathway Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response Response To Stress Antimicrobial Humoral Response CCR Chemokine Receptor Binding Regulation Of Neutrophil Chemotaxis Cytokine Activity Regulation Of Neutrophil Migration T Cell Costimulation Nitrate Transmembrane Transporter Activity Immune System Process Cell Surface Positive Regulation Of T Cell Activation Regulation Of Granulocyte Chemotaxis Glucagon Processing Regulation Of Cell Activation Humoral Immune Response Positive Regulation Of Dendritic Cell Dendrite Assembly Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion Response To Hypoxia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Extracellular Region Response To Lipid Response To Oxygen Levels Response To Decreased Oxygen Levels Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Cellular Response To Thyroxine Stimulus Negative Regulation Of Hepatic Stellate Cell Activation Glutamate-cysteine Ligase Activity Glutamate-cysteine Ligase Complex Granulocyte Chemotaxis CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Peripheral Nervous System Neuron Differentiation Response To Heat Granulocyte Migration Cell Adhesion Molecule Binding Regulation Of Leukocyte Cell-cell Adhesion