GCLC and CCL22

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GCLC	CCL22
Gene Name		glutamate-cysteine ligase, catalytic subunit	chemokine (C-C motif) ligand 22
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex	Extracellular Region Extracellular Space
	Molecular Function	Magnesium Ion Binding Glutamate-cysteine Ligase Activity ATP Binding Glutamate Binding ADP Binding Protein Heterodimerization Activity Coenzyme Binding	Chemokine Activity
	Biological Process	Sulfur Amino Acid Metabolic Process Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Xenobiotic Metabolic Process Response To Oxidative Stress Apoptotic Mitochondrial Changes Response To Heat Response To Hormone L-ascorbic Acid Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Cell Redox Homeostasis Negative Regulation Of Transcription, DNA-templated Response To Arsenic-containing Substance Regulation Of Blood Vessel Size Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Glutathione Derivative Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Cell Chemotaxis
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Sulfur amino acid metabolism Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Glutathione conjugation Metabolism of amino acids and derivatives Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		L-Glutamic Acid L-Cysteine
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CCL22 GCLM	7 interactors: CCL19 CCR4 CRYAB DPP4 GCLC HERC3 VCAM1
Entrez ID		2729	6367
HPRD ID		06032	04263
Ensembl ID		ENSG00000001084	ENSG00000102962
Uniprot IDs		E1CEI4 P48506 Q14TF0	O00626
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glutamate-cysteine Ligase Activity Response To Nitrosative Stress Cysteine Metabolic Process Regulation Of Mitochondrial Depolarization Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Glutamate Metabolic Process Peptide Biosynthetic Process Regulation Of Membrane Depolarization Sulfur Amino Acid Metabolic Process Serine Family Amino Acid Metabolic Process Glutathione Metabolic Process Apoptotic Mitochondrial Changes Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Ligase Activity Dicarboxylic Acid Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Regulation Of Ion Homeostasis Cell Chemotaxis Negative Regulation Of Neuron Apoptotic Process	Response To Abiotic Stimulus Positive Regulation Of T Cell Activation Cellular Homeostasis Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Proliferation Cell Migration Response To Lipid Response To Stress Response To Hypoxia Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cell Motility Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Response To Oxidative Stress Inflammatory Response T Cell Costimulation Response To Radiation Response To Organic Substance Locomotion Response To Inorganic Substance Regulation Of Cell Activation Positive Regulation Of T Cell Proliferation Leukocyte Activation Positive Regulation Of Dendritic Cell Dendrite Assembly Homeostatic Process Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis Positive Regulation Of Chemotaxis Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Stress-activated MAPK Cascade Positive Regulation Of Lymphocyte Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Mononuclear Cell Proliferation Chemotaxis Regulation Of Cell Adhesion Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Activation Response To Ionizing Radiation Regulation Of T Cell Proliferation Immune System Development Myeloid Dendritic Cell Chemotaxis Regulation Of Dendritic Cell Dendrite Assembly
Tagcloud ?		acetaminophen acetylcysteine antidote apap assessments augmenter constituents exerted exerts gclm hepatotoxicity histologic ho injured livers morphologic nac nqo1 poisoning possessed postdosing proliferating regenerative rescue schisandra sphenanthera tablet wuzhi wz	27cm3 39cm3 alternatively capacities cd163 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Difference) ?		acetaminophen acetylcysteine antidote apap assessments augmenter constituents exerted exerts gclm hepatotoxicity histologic ho injured livers morphologic nac nqo1 poisoning possessed postdosing proliferating regenerative rescue schisandra sphenanthera tablet wuzhi wz	27cm3 39cm3 alternatively capacities cd163 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Intersection) ?