GCLC

Gene Name		glutamate-cysteine ligase, catalytic subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex
	Molecular Function	Magnesium Ion Binding Glutamate-cysteine Ligase Activity ATP Binding Glutamate Binding ADP Binding Protein Heterodimerization Activity Coenzyme Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Xenobiotic Metabolic Process Response To Oxidative Stress Apoptotic Mitochondrial Changes Response To Heat Response To Hormone L-ascorbic Acid Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Cell Redox Homeostasis Negative Regulation Of Transcription, DNA-templated Response To Arsenic-containing Substance Regulation Of Blood Vessel Size Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Glutathione Derivative Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Sulfur amino acid metabolism Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Glutathione conjugation Metabolism of amino acids and derivatives Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		L-Glutamic Acid L-Cysteine
Diseases
GWAS
Protein-protein Interactions		2 interactors: CCL22 GCLM
Entrez ID		2729
HPRD ID		06032
Ensembl ID		ENSG00000001084
Uniprot IDs		E1CEI4 P48506 Q14TF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glutamate-cysteine Ligase Activity Response To Nitrosative Stress Cysteine Metabolic Process Regulation Of Mitochondrial Depolarization Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Glutamate Metabolic Process Peptide Biosynthetic Process Regulation Of Membrane Depolarization Sulfur Amino Acid Metabolic Process Serine Family Amino Acid Metabolic Process Glutathione Metabolic Process Apoptotic Mitochondrial Changes Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Ligase Activity Dicarboxylic Acid Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Regulation Of Ion Homeostasis Cell Chemotaxis Negative Regulation Of Neuron Apoptotic Process
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