CPAMD8 and SCTR

Number of citations of the paper that reports this interaction (PMID 1335692)
2

Data Source:
HPRD (in vitro, in vivo)

		CPAMD8	SCTR
Gene Name		C3 and PZP-like, alpha-2-macroglobulin domain containing 8	secretin receptor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane	Cytoplasmic Microtubule Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Secretin Receptor Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity	G-protein Coupled Receptor Signaling Pathway Digestion Excretion
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Secretin
Diseases
GWAS		Brain lesion load ( 19010793) Crohn's disease ( 22412388)
Protein-Protein Interactions		3 interactors: ADCYAP1 DPP4 SCTR	9 interactors: ADCYAP1 CALM1 CPAMD8 CYFIP1 DNAL4 PRKAR2A PRKCA SCT SNTA1
Entrez ID		27151	6344
HPRD ID		09892	01628
Ensembl ID		ENSG00000160111	ENSG00000080293
Uniprot IDs		Q6NVW5 Q8IZJ3	P47872 Q8IV17
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Somatostatin Secretion Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Growth Hormone Secretion Regulation Of Cell-cell Adhesion Mediated By Integrin Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Rho GTPase Activity Negative Regulation Of Acute Inflammatory Response Histamine Secretion Positive Regulation Of Rap GTPase Activity Histamine Transport Negative Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity CAMP-mediated Signaling Negative Regulation Of Potassium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Rap Protein Signal Transduction Positive Regulation Of Cell Proliferation Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Vasodilation Negative Regulation Of GTPase Activity Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Adenylate Cyclase Activity Behavioral Fear Response Regulation Of Extracellular Matrix Organization Fear Response Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Vasodilation Excretion Positive Regulation Of Lyase Activity Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Muscle Cell Apoptotic Process Pituitary Gland Development Regulation Of Adenylate Cyclase Activity	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Phospholipase C Activity Response To Growth Factor Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lipase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Muscle Contraction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Protein Metabolic Process Regulation Of Rhodopsin Mediated Signaling Pathway Response To Fibroblast Growth Factor Rhodopsin Mediated Signaling Pathway Regulation Of Peptide Hormone Secretion Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Hormone Secretion Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Response To Light Stimulus Positive Regulation Of Protein Modification Process Intracellular Signal Transduction Cellular Response To Organic Substance
Tagcloud ?			abolishes acts angii angiotensin axis coexpresses erralpha hyperosmolality hyperosmotic hypertonic hypothalamic hypothalamus importantly lamina mediate nr3b1 osmoregulation osmoregulatory paraventricular salt secretin stimulations terminalis upregulates upstream vasopressin vital vp
Tagcloud (Difference) ?			abolishes acts angii angiotensin axis coexpresses erralpha hyperosmolality hyperosmotic hypertonic hypothalamic hypothalamus importantly lamina mediate nr3b1 osmoregulation osmoregulatory paraventricular salt secretin stimulations terminalis upregulates upstream vasopressin vital vp
Tagcloud (Intersection) ?