CPAMD8 and SCTR

Number of citations: 0 (PubMedID 1335692)
Data Source: HPRD (in vivo, in vitro)

		CPAMD8	SCTR
Name		C3 and PZP like alpha-2-macroglobulin domain containing 8	secretin receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Cytoplasmic Microtubule Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Secretin Receptor Activity Peptide Hormone Binding
	Biological Process	Eye Development	Diet Induced Thermogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Water Homeostasis Response To Nutrient Levels Regulation Of Appetite Regulation Of Synaptic Plasticity
Pathways		None	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		None	Secretin human
GWAS		Brain lesion load ( 19010793 ) Cataracts ( 34127677 ) Crohn's disease ( 22412388 ) Height ( 28552196 ) Retinal detachment or retinal break ( 31816047 )	Bipolar disorder ( 31043756 ) Type 2 diabetes ( 30718926 32499647 )
Interacting Genes		3 interacting genes: ADCYAP1 DPP4 SCTR	9 interacting genes: ADCYAP1 CALM1 CPAMD8 CYFIP1 DNAL4 PRKAR2A PRKCA SCT SNTA1
Entrez ID		27151	6344
HPRD ID		09892	01628
Ensembl ID		ENSG00000160111	ENSG00000080293
Uniprot IDs		A0A494C0S9 Q8IZJ3	P47872 Q8IV17
PDB IDs		Not available	6WI9 6WZG 7D3S
GO Terms Enriched among Interactors		Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Glucagon Processing Secretin Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Peptide Hormone Receptor Binding Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Growth Hormone Secretion Intercellular Canaliculus Negative Regulation Of Extracellular Matrix Disassembly Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Neutrophil Migration Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Neutrophil Chemotaxis Dipeptidyl-peptidase Activity Psychomotor Behavior Virion Attachment To Host Cell Diet Induced Thermogenesis Intracellular Water Homeostasis Regulation Of Growth Hormone Secretion Activation Of Adenylate Cyclase Activity Adhesion Of Symbiont To Host Endocytosis Involved In Viral Entry Into Host Cell Locomotory Exploration Behavior Regulation Of Hormone Levels Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Regulation Of Biological Quality Positive Regulation Of Cyclase Activity Negative Regulation Of Extracellular Matrix Organization Lamellipodium Membrane Negative Regulation Of Leukocyte Chemotaxis Regulation Of Extracellular Matrix Disassembly Chemorepellent Activity Adaptive Thermogenesis Regulation Of Appetite Motor Behavior Neuropeptide Hormone Activity Aminopeptidase Activity Regulation Of Neutrophil Chemotaxis G Protein-coupled Receptor Signaling Pathway Behavioral Fear Response Exploration Behavior Behavioral Defense Response	Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Regulation Of System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion Pituitary Adenylate Cyclase Activating Polypeptide Activity Positive Regulation Of Secretion By Cell Protein-containing Complex Positive Regulation Of Somatostatin Secretion Negative Regulation Of Gastrin-induced Gastric Acid Secretion Digestive Hormone Activity Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Cell Communication Signaling Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Pancreatic Juice Secretion Regulation Of Heart Rate Regulation Of Signal Transduction Hormone Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase C Signaling Negative Regulation Of Gastric Acid Secretion Syntrophin Complex Regulation Of Translation At Postsynapse Regulation Of Hormone Levels Extracellular Region Transmembrane Transporter Binding Regulation Of Secretion By Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane