OPLAH

Description		5-oxoprolinase, ATP-hydrolysing
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Hydrolase Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Identical Protein Binding
	Biological Process	Glutathione Metabolic Process
Pathways		Glutathione synthesis and recycling Defective OPLAH causes OPLAHD
Drugs		Glutamic acid
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		6 interacting genes: GK HOXA1 POU6F2 TPK1 UBC ZNF451
Entrez ID		26873
HPRD ID		14880
Ensembl ID		ENSG00000178814
Uniprot IDs		O14841
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Semicircular Canal Formation UTP Thiamine Diphosphokinase Activity Thiamine Binding Thiamine Diphosphokinase Activity Abducens Nerve Formation Optokinetic Behavior Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Metabolic Process Mitochondrial Outer Membrane Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Initiation Thiamine-containing Compound Metabolic Process Embryonic Neurocranium Morphogenesis Outer Ear Morphogenesis Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Alcohol Metabolic Process Phosphotransferase Activity, Alcohol Group As Acceptor DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Ligase Activity Glycerol Metabolic Process Protein Tag Activity Triglyceride Biosynthetic Process
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