OPLAH and TPK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OPLAH	TPK1
Description		5-oxoprolinase, ATP-hydrolysing	thiamin pyrophosphokinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Hydrolase Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Identical Protein Binding	Nucleotide Binding Thiamine Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Thiamine Binding Identical Protein Binding UTP Thiamine Diphosphokinase Activity
	Biological Process	Glutathione Metabolic Process	Thiamine Metabolic Process Thiamine Diphosphate Biosynthetic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA
Pathways		Glutathione synthesis and recycling Defective OPLAH causes OPLAHD	Vitamin B1 (thiamin) metabolism
Drugs		Glutamic acid	Thiamine Pyrithiamine Pyrophosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748)	Fruit consumption ( 32066663) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Iris color (b* coordinate) ( 30895295) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		6 interacting genes: GK HOXA1 POU6F2 TPK1 UBC ZNF451	1 interacting genes: OPLAH
Entrez ID		26873	27010
HPRD ID		14880	06967
Ensembl ID		ENSG00000178814	ENSG00000196511
Uniprot IDs		O14841	A0A090N8Y0 B3KRJ6 F5GZG6 Q6ZQX6 Q9H3S4
PDB IDs			3S4Y 9HJC
Enriched GO Terms of Interacting Partners?		Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Semicircular Canal Formation UTP Thiamine Diphosphokinase Activity Thiamine Binding Thiamine Diphosphokinase Activity Abducens Nerve Formation Optokinetic Behavior Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Metabolic Process Mitochondrial Outer Membrane Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Initiation Thiamine-containing Compound Metabolic Process Embryonic Neurocranium Morphogenesis Outer Ear Morphogenesis Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Alcohol Metabolic Process Phosphotransferase Activity, Alcohol Group As Acceptor DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Ligase Activity Glycerol Metabolic Process Protein Tag Activity Triglyceride Biosynthetic Process	5-oxoprolinase (ATP-hydrolyzing) Activity Glutathione Metabolic Process
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