GJB6 and GJB2

Number of citations of the paper that reports this interaction (PubMedID 14595769)
0

Data Source:
HPRD (in vivo)

		GJB6	GJB2
Description		gap junction protein beta 6	gap junction protein beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Actin Filament Plasma Membrane Gap Junction Connexin Complex Membrane Apical Plasma Membrane Cell Junction Anchoring Junction	Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Gap Junction Channel Activity Protein Binding Microtubule Binding Beta-tubulin Binding Actin Filament Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	Gap Junction Channel Activity Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Sinoatrial Node Development Cell Communication Cell-cell Signaling Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Cell Communication By Electrical Coupling Gap Junction Assembly Response To Lipopolysaccharide Maintenance Of Blood-brain Barrier Ear Morphogenesis Inner Ear Development Response To Electrical Stimulus Transmembrane Transport Cellular Response To Glucose Stimulus Gap Junction-mediated Intercellular Transport	Cell Communication Cell-cell Signaling Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		Gap junction assembly	Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane
Drugs
Diseases		Deafness, autosomal recessive Ectodermal dysplasia, hidrotic; Clouston syndrome	Deafness, autosomal recessive Keratitis-ichthyosis-deafness syndrome Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis Deafness, autosomal dominant Palmoplantar keratoderma with deafness
GWAS		Facial emotion recognition (happy faces) ( 28608620) Triglyceride levels x fish oil supplementation interaction (1df) ( 33760818)	Facial emotion recognition (happy faces) ( 28608620)
Interacting Genes		14 interacting genes: CHRM5 CNST EBP F2RL1 GJB2 GPR61 KLRC1 LHFPL5 MS4A13 SEC22A SEC22B SLC10A6 TMEM218 TMEM60	44 interacting genes: AMIGO1 APLNR AQP6 ARL13B CAV1 CD14 CNST CREB3 EBP ERGIC3 FAM209A FFAR2 GJA5 GJA8 GJB1 GJB6 GPR152 GPR42 HSD17B13 KCNK5 KLRC1 LHFPL5 LMNA LRRC4C MFSD6 MS4A6E PEX12 PLEKHB2 SAR1A SHISAL1 SLC10A6 SLC18A1 SLC30A2 SSMEM1 TBXA2R TEX29 TIMMDC1 TLCD4 TM2D2 TMEM106A TMEM237 TMEM31 TMX2 TRHR
Entrez ID		10804	2706
HPRD ID		05107	00413
Ensembl ID		ENSG00000121742	ENSG00000165474
Uniprot IDs		O95452	H9U1J4 P29033
PDB IDs			2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG 6UVR 6UVS 6UVT 7QEO 7QEQ 7QER 7QES 7QET 7QEU 7QEV 7QEW 7QEY 8Q9Z 8QA0 8QA1 8QA2 8QA3
Enriched GO Terms of Interacting Partners?		Membrane Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Cell Killing Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Renin Secretion Into Blood Stream Endoplasmic Reticulum-Golgi Intermediate Compartment HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Inhibitory MHC Class Ib Receptor Activity SNAP Receptor Activity Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Steroid Delta-isomerase Activity Cholestenol Delta-isomerase Activity Ligand-independent Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport	Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Gap Junction Assembly Protein Binding Plasma Membrane Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Vasoconstriction Connexin Binding Atrioventricular Valve Development Gap Junction-mediated Intercellular Transport Regulation Of Gap Junction Assembly Intercellular Transport G Protein-coupled Receptor Activity Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Muscle System Process Transmembrane Transport Regulation Of Vasoconstriction
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