GJB6 and SEC22B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJB6	SEC22B
Description		gap junction protein beta 6	SEC22 homolog B, vesicle trafficking protein
Image		No pdb structure
GO Annotations	Cellular Component	Actin Filament Plasma Membrane Gap Junction Connexin Complex Membrane Apical Plasma Membrane Cell Junction Anchoring Junction	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome
	Molecular Function	Gap Junction Channel Activity Protein Binding Microtubule Binding Beta-tubulin Binding Actin Filament Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	SNAP Receptor Activity Protein Binding
	Biological Process	Sinoatrial Node Development Cell Communication Cell-cell Signaling Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Cell Communication By Electrical Coupling Gap Junction Assembly Response To Lipopolysaccharide Maintenance Of Blood-brain Barrier Ear Morphogenesis Inner Ear Development Response To Electrical Stimulus Transmembrane Transport Cellular Response To Glucose Stimulus Gap Junction-mediated Intercellular Transport	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process Membrane Fusion Negative Regulation Of Autophagosome Assembly
Pathways		Gap junction assembly	ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases		Deafness, autosomal recessive Ectodermal dysplasia, hidrotic; Clouston syndrome
GWAS		Facial emotion recognition (happy faces) ( 28608620) Triglyceride levels x fish oil supplementation interaction (1df) ( 33760818)	Iris color (L* coordinate) ( 30895295)
Interacting Genes		14 interacting genes: CHRM5 CNST EBP F2RL1 GJB2 GPR61 KLRC1 LHFPL5 MS4A13 SEC22A SEC22B SLC10A6 TMEM218 TMEM60	57 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MGST2 MGST3 MMGT1 MRPS18B MUC1 NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC10A6 SLC35H1 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM132D TMEM139 TMEM167B TMEM229B TMEM86B
Entrez ID		10804	9554
HPRD ID		05107	04939
Ensembl ID		ENSG00000121742	ENSG00000265808
Uniprot IDs		O95452	O75396
PDB IDs			2NUP 2NUT 3EGD 3EGX 8HR0
Enriched GO Terms of Interacting Partners?		Membrane Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Cell Killing Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Renin Secretion Into Blood Stream Endoplasmic Reticulum-Golgi Intermediate Compartment HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Inhibitory MHC Class Ib Receptor Activity SNAP Receptor Activity Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Steroid Delta-isomerase Activity Cholestenol Delta-isomerase Activity Ligand-independent Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport	Membrane Endoplasmic Reticulum Membrane SNARE Complex SNARE Binding SNAP Receptor Activity Exocytosis Endoplasmic Reticulum Protein Binding Positive Regulation Of Regulated Secretory Pathway Connexin Complex Gap Junction Channel Activity Secretion By Cell Vesicle Docking Glutathione Peroxidase Activity Gap Junction Leukotriene-C4 Synthase Activity Cornified Envelope Assembly Organelle Localization By Membrane Tethering Gap Junction-mediated Intercellular Transport Positive Regulation Of Exocytosis Membrane Docking Secretion Vesicle Fusion Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Organelle Membrane Fusion Intercellular Transport SNARE Complex Assembly Lipid Metabolic Process Regulation Of Regulated Secretory Pathway Membrane Assembly Organelle Fusion Regulation Of Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
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