NPTN and AATF

		NPTN	AATF
Description		neuroplastin	apoptosis antagonizing transcription factor
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GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell Surface Postsynaptic Density Membrane Axon Dendrite Presynaptic Membrane Synapse	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Small-subunit Processome
	Molecular Function	Type 1 Fibroblast Growth Factor Receptor Binding Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity	RNA Binding Protein Binding Leucine Zipper Domain Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Intracellular Calcium Ion Homeostasis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Synapse Organization Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Long-term Synaptic Potentiation Dendrite Self-avoidance Regulation Of Receptor Localization To Synapse Excitatory Synapse Assembly	Cell Adhesion Regulation Of Mitotic Cell Cycle Embryonic Cleavage Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		GABA receptor activation	NRAGE signals death through JNK
Drugs
Diseases
GWAS		Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications ( 28100913) Tourette syndrome ( 30818990) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 26426971) Erectile dysfunction ( 30583798) Obesity-related traits ( 23251661) Thyroid volume in Hashimoto’s thyroiditis ( 32019955)
Interacting Genes		3 interacting genes: AGTR1 SURF2 UBC	29 interacting genes: ATM ATR AURKA CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 FBXO7 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 MYCBP2 NEDD4L PALS2 PARP1 PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468
Entrez ID		27020	26574
HPRD ID		18033	12236
Ensembl ID		ENSG00000156642	ENSG00000275700
Uniprot IDs		Q9Y639	A0A7P0TAR0 A0A7P0TBG4 Q9NY61
PDB IDs		6A69	5W6A 7MQ8 7MQ9
Enriched GO Terms of Interacting Partners?		Angiotensin Type I Receptor Activity Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Renal Sodium Excretion Embryonic Cleavage Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Leucine Zipper Domain Binding Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Low-density Lipoprotein Particle Remodeling Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Protein Tag Activity Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Glycoprotein Biosynthetic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cholesterol Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation	Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Replicative Senescence Positive Regulation Of Metabolic Process Response To Gamma Radiation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Organelle Organization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death PML Body Chromatin Organization Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Mitotic Nuclear Division Regulation Of Cellular Response To Heat Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly G2/M Transition Of Mitotic Cell Cycle Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cell Cycle G2/M Phase Transition Apoptotic Process Protein Homodimerization Activity Positive Regulation Of Cellular Component Organization Regulation Of Protein Stability Regulation Of Protein Catabolic Process Nucleoplasm Programmed Cell Death
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