DNAJC2 and HIST2H2AA3

Number of citations of the paper that reports this interaction (PMID 21179169)
15

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DNAJC2	HIST2H2AA3
Gene Name		DnaJ (Hsp40) homolog, subfamily C, member 2	histone cluster 2, H2aa3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Membrane	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Hsp70 Protein Binding Histone Binding Ubiquitin Binding Poly(A) RNA Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	DNA Replication Transcription, DNA-templated Chromatin Modification Negative Regulation Of Cell Growth Positive Regulation Of Transcription, DNA-templated 'de Novo' Cotranslational Protein Folding Negative Regulation Of DNA Biosynthetic Process	Biological_process
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: HIST2H2AA3 HSPA14	16 interactors: APP BAP1 BMI1 DNAJC2 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF2 RNF20 TBL1X UBE2H USP16 USP21
Entrez ID		27000	8337
HPRD ID		19072	08851
Ensembl ID		ENSG00000105821
Uniprot IDs		Q99543	Q6FI13
PDB IDs		2M2E
Enriched GO Terms of Interacting Partners?		'de Novo' Cotranslational Protein Folding 'de Novo' Protein Folding	Chromosome Organization Chromatin Organization Chromatin Modification Histone Modification Organelle Organization Histone Ubiquitination Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Histone Deubiquitination Histone Monoubiquitination Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Protein Monoubiquitination Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Catabolic Process
Tagcloud ?		actually bear categorized cerevisiae contain dnaja1 dnajb1b domains dubbed folding highlights homologs hsp40 hsp70s hydrolysis introduces named names preserved saccharomyces stabilizing stresses studying unfolding
Tagcloud (Difference) ?		actually bear categorized cerevisiae contain dnaja1 dnajb1b domains dubbed folding highlights homologs hsp40 hsp70s hydrolysis introduces named names preserved saccharomyces stabilizing stresses studying unfolding
Tagcloud (Intersection) ?