DNAJC2 and HSPA14

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, cross-linking study, cross-linking study)
HPRD (in vitro)

		DNAJC2	HSPA14
Description		DnaJ heat shock protein family (Hsp40) member C2	heat shock protein family A (Hsp70) member 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Membrane	Nucleus Cytoplasm Cytosol Ribosome Plasma Membrane Membrane
	Molecular Function	ATPase Activator Activity Chromatin Binding RNA Binding Protein Binding Hsp70 Protein Binding Histone Binding Ribosome Binding Ubiquitin-modified Histone Reader Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone
	Biological Process	DNA Replication Chromatin Organization Regulation Of Translational Fidelity Positive Regulation Of DNA-templated Transcription 'de Novo' Cotranslational Protein Folding Regulation Of Cellular Response To Heat Negative Regulation Of DNA Biosynthetic Process	Protein Folding Protein Refolding 'de Novo' Cotranslational Protein Folding
Pathways		Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS			Night sleep phenotypes ( 27126917) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		2 interacting genes: H2AC18 HSPA14	8 interacting genes: BARD1 BRCA1 CFTR DNAJC2 FAM107A OGT PAXIP1 STIP1
Entrez ID		27000	51182
HPRD ID		19072	07021
Ensembl ID		ENSG00000105821	ENSG00000187522
Uniprot IDs		Q99543	Q0VDF9
PDB IDs		2M2E 6CGH
Enriched GO Terms of Interacting Partners?		'de Novo' Cotranslational Protein Folding 'de Novo' Protein Folding Protein Refolding ATP-dependent Protein Folding Chaperone	Ubiquitin-modified Histone Reader Activity Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Chromatin Organization Regulation Of Cell Cycle G2/M Phase Transition DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cell Cycle Phase Transition Response To Ionizing Radiation Regulation Of DNA Metabolic Process Regulation Of DNA Damage Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein K6-linked Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Homologous Recombination DNA Recombination Regulation Of Post-translational Protein Modification DNA Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Protein-containing Complex Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Metabolic Process Nucleus Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of MRNA 3'-end Processing Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Response To Radiation Positive Regulation Of Anion Channel Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle
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