GFRA2 and GDNF

Number of citations of the paper that reports this interaction (PMID 9407096)
12

Data Source:
HPRD (in vitro)

		GFRA2	GDNF
Gene Name		GDNF family receptor alpha 2	glial cell derived neurotrophic factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane	Extracellular Region
	Molecular Function	Glial Cell-derived Neurotrophic Factor Receptor Activity	Receptor Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Negative Regulation Of Protein Autophosphorylation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Axon Guidance Adult Locomotory Behavior Postganglionic Parasympathetic Nervous System Development Peristalsis Neuron Projection Development Positive Regulation Of Monooxygenase Activity Positive Regulation Of Dopamine Secretion Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Major depressive disorder ( 20125088)
Protein-Protein Interactions		2 interactors: GDNF NRTN	5 interactors: AGTRAP GFRA1 GFRA2 NCAM1 RET
Entrez ID		2675	2668
HPRD ID		11801	02906
Ensembl ID		ENSG00000168546	ENSG00000168621
Uniprot IDs		O00451	P39905
PDB IDs			2V5E 3FUB
Enriched GO Terms of Interacting Partners?		Neural Crest Cell Migration Neural Crest Cell Development Neural Crest Cell Differentiation Mesenchymal Cell Development Mesenchymal Cell Differentiation Ameboidal-type Cell Migration Mesenchyme Development Stem Cell Development Postganglionic Parasympathetic Nervous System Development Stem Cell Differentiation Axon Guidance Ureteric Bud Formation Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Dopamine Secretion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Mesonephric Tubule Formation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neuron Projection Morphogenesis Positive Regulation Of Catecholamine Secretion Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cell Morphogenesis Involved In Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Enteric Nervous System Development Peristalsis Neuron Projection Development Regulation Of Neurotransmitter Uptake Metanephric Renal Vesicle Morphogenesis Cell Migration Cell Projection Morphogenesis Renal Vesicle Morphogenesis Cell Part Morphogenesis Cell Motility Mesenchymal To Epithelial Transition Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Synaptic Transmission, Dopaminergic Parasympathetic Nervous System Development Nephron Tubule Formation Neuron Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Dopamine Secretion Sympathetic Nervous System Development Positive Regulation Of Monooxygenase Activity Cell Morphogenesis Metanephric Nephron Morphogenesis MRNA Stabilization Neuron Differentiation	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Posterior Midgut Development Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Response To Organic Substance Positive Regulation Of Neuron Maturation Neuron Development Signaling Lymphocyte Migration Into Lymphoid Organs Cell Communication Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Neuron Differentiation Ureter Maturation Regulation Of Neuron Maturation Locomotion Angiotensin-activated Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Glomerulus Development Negative Regulation Of Protein Autophosphorylation Movement Of Cell Or Subcellular Component Generation Of Neurons Axon Guidance Enteric Nervous System Development Neurogenesis Neuron Cell-cell Adhesion Positive Regulation Of Cell Size Ureter Development Positive Regulation Of Cell Adhesion Mediated By Integrin Peyer's Patch Development Cell Development System Development Midgut Development Axonogenesis Response To Stimulus Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Autophosphorylation Chemotaxis Neuron Maturation Lymphocyte Migration Multicellular Organismal Development Neuron Projection Morphogenesis
Tagcloud ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits fbln1 filopodia fmn2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	coimmunoprecipitation crest displays docking enlightening fmtc grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements ret separately shc
Tagcloud (Difference) ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits fbln1 filopodia fmn2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide parm peri protrusions punctate semi	coimmunoprecipitation crest displays docking enlightening fmtc grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements ret separately shc
Tagcloud (Intersection) ?		oncogenes