GFRA2

Description		GDNF family receptor alpha 2
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Receptor Complex Side Of Membrane
	Molecular Function	Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity Heparan Sulfate Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Migraine with aura ( 23793025) Neuropathic pain in type 2 diabetes ( 24974787) Nicotine dependence symptom count ( 25555482) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to lithium treatment in bipolar disorder (continuous phenotype) ( 26806518) Trunk fat mass ( 28552196) Verbal declarative memory ( 25648963)
Novel Interacting Genes		1 novel interacting genes: PPP3CC
Interacting Genes		2 interacting genes: GDNF NRTN
Entrez ID		2675
HPRD ID		11801
Ensembl ID		ENSG00000168546
Uniprot IDs		O00451
PDB IDs		5MR4 5MR5 6GL7 6Q2O 6Q2R
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neural Crest Cell Migration Receptor Tyrosine Kinase Binding Mesenchymal Cell Migration Ameboidal-type Cell Migration Growth Factor Activity Chemoattractant Activity Involved In Axon Guidance Postganglionic Parasympathetic Fiber Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesonephric Tubule Formation Autonomic Nervous System Development Ureteric Bud Formation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Ureteric Bud Formation Dorsal Spinal Cord Development Positive Regulation Of Dopamine Secretion Chemoattraction Of Axon Regulation Of Semaphorin-plexin Signaling Pathway Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Synaptic Vesicle Recycling Calcium-dependent Protein Serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Calcineurin Complex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Receptor Binding Postsynaptic Membrane Organization Positive Regulation Of Epithelial Tube Formation Heparan Sulfate Binding Protein Serine/threonine Phosphatase Complex Positive Regulation Of Calcium Ion Import Across Plasma Membrane Peristalsis Positive Regulation Of Catecholamine Secretion Enteric Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nephron Tubule Formation Neuron Projection Development Commissural Neuron Axon Guidance Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal To Epithelial Transition Sympathetic Nervous System Development Nervous System Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Neurotransmitter Uptake Calcineurin-NFAT Signaling Cascade
Tagcloud ?