GFRA2 and NRTN

Number of citations of the paper that reports this interaction (PMID 9407096)
12

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		GFRA2	NRTN
Gene Name		GDNF family receptor alpha 2	neurturin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane	Extracellular Region Axon
	Molecular Function	Glial Cell-derived Neurotrophic Factor Receptor Activity	Receptor Binding Growth Factor Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Negative Regulation Of Protein Autophosphorylation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	MAPK Cascade Neural Crest Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Nerve Development Neuron Projection Development
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			N-glycan levels ( 21203500)
Protein-Protein Interactions		2 interactors: GDNF NRTN	3 interactors: GFRA1 GFRA2 RET
Entrez ID		2675	4902
HPRD ID		11801	03604
Ensembl ID		ENSG00000168546	ENSG00000171119
Uniprot IDs		O00451	Q99748
PDB IDs
Enriched GO Terms of Interacting Partners?		Neural Crest Cell Migration Neural Crest Cell Development Neural Crest Cell Differentiation Mesenchymal Cell Development Mesenchymal Cell Differentiation Ameboidal-type Cell Migration Mesenchyme Development Stem Cell Development Postganglionic Parasympathetic Nervous System Development Stem Cell Differentiation Axon Guidance Ureteric Bud Formation Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Dopamine Secretion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Mesonephric Tubule Formation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neuron Projection Morphogenesis Positive Regulation Of Catecholamine Secretion Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cell Morphogenesis Involved In Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Enteric Nervous System Development Peristalsis Neuron Projection Development Regulation Of Neurotransmitter Uptake Metanephric Renal Vesicle Morphogenesis Cell Migration Cell Projection Morphogenesis Renal Vesicle Morphogenesis Cell Part Morphogenesis Cell Motility Mesenchymal To Epithelial Transition Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Synaptic Transmission, Dopaminergic Parasympathetic Nervous System Development Nephron Tubule Formation Neuron Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Dopamine Secretion Sympathetic Nervous System Development Positive Regulation Of Monooxygenase Activity Cell Morphogenesis Metanephric Nephron Morphogenesis MRNA Stabilization Neuron Differentiation	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Maturation Lymphocyte Migration Into Lymphoid Organs Cellular Response To Organic Substance Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Ureter Maturation Regulation Of Neuron Maturation Nervous System Development Cytokine-mediated Signaling Pathway Positive Regulation Of Glomerulus Development Negative Regulation Of Protein Autophosphorylation Response To Organic Substance Enteric Nervous System Development Cellular Response To Cytokine Stimulus Neuron Cell-cell Adhesion Positive Regulation Of Cell Size Ureter Development Positive Regulation Of Cell Adhesion Mediated By Integrin Peyer's Patch Development Cell Surface Receptor Signaling Pathway Midgut Development Response To Cytokine Regulation Of Protein Autophosphorylation Neuron Maturation Lymphocyte Migration Membrane Protein Proteolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Innervation Positive Regulation Of Kidney Development Neuron Development Response To Pain Regulation Of Cell Adhesion Mediated By Integrin Autonomic Nervous System Development System Development Neural Crest Cell Migration Neuron Differentiation Locomotion Multicellular Organismal Development Neural Crest Cell Development Cellular Response To Retinoic Acid Anatomical Structure Development Neural Crest Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Signal Transduction Multicellular Organismal Response To Stress
Tagcloud ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits fbln1 filopodia fmn2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	bain biol dev division es excitotoxic gdnf gfralpha1 gfralpha2 grown immunocytochemistry injured ligands likelihood lineage manipulable modestly neurons neurotrophin neurotrophins neurturin nmda nt oligodendrocytes plating pluripotential pretreatment ret vulnerability
Tagcloud (Difference) ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits fbln1 filopodia fmn2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	bain biol dev division es excitotoxic gdnf gfralpha1 gfralpha2 grown immunocytochemistry injured ligands likelihood lineage manipulable modestly neurons neurotrophin neurotrophins neurturin nmda nt oligodendrocytes plating pluripotential pretreatment ret vulnerability
Tagcloud (Intersection) ?