PLEK2 and INPPL1

Number of citations of the paper that reports this interaction (PubMedID 31498891)
0

Data Source:
BioGRID (pull down)

		PLEK2	INPPL1
Description		pleckstrin 2	inositol polyphosphate phosphatase like 1
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Membrane Cell Projection	Spindle Pole Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Basal Plasma Membrane Membrane Nuclear Speck Lamellipodium Filopodium Cell Projection
	Molecular Function	Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Actin Binding Inositol-polyphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity SH2 Domain Binding
	Biological Process	Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Intracellular Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly	Establishment Of Mitotic Spindle Orientation Endochondral Ossification Immune System Process Glucose Metabolic Process Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Apoptotic Process Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Gene Expression Negative Regulation Of Gene Expression Response To Insulin Regulation Of Protein Localization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol Dephosphorylation Regulation Of Immune Response ERK1 And ERK2 Cascade Ruffle Assembly Regulation Of Actin Filament Organization
Pathways			Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Broad depression or major depressive disorder (recurrent) ( 30626913) Depressive symptom measurement or major depressive disorder ( 28049566) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494)	Heart rate response to recovery post exercise (10 sec) ( 29497042)
Interacting Genes		1 interacting genes: INPPL1	23 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 LNCAROD MET PLEK2 SHC1 SORBS1 SORBS3 SRC UBC
Entrez ID		26499	3636
HPRD ID		12151	02900
Ensembl ID		ENSG00000100558	ENSG00000165458
Uniprot IDs		Q9NYT0	O15357
PDB IDs		1X1G	2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP 6SQU 6SRR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Ruffle Assembly Establishment Of Spindle Orientation Phospholipid Dephosphorylation Endochondral Ossification SH2 Domain Binding Phosphatidylinositol Dephosphorylation Establishment Of Mitotic Spindle Localization Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Ruffle Organization Establishment Of Spindle Localization ERK1 And ERK2 Cascade Spindle Localization Basal Plasma Membrane Post-embryonic Development Filopodium Phosphatase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ossification Phosphatidylinositol Metabolic Process Glucose Metabolic Process SH3 Domain Binding Dephosphorylation Phosphatidylinositol Biosynthetic Process Microtubule Cytoskeleton Organization Involved In Mitosis Lipid Modification Hexose Metabolic Process Spindle Pole Response To Insulin Glycerophospholipid Biosynthetic Process Monosaccharide Metabolic Process Lamellipodium Phospholipid Biosynthetic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus ERBB2 Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Growth Factor Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Focal Adhesion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Apoptotic Process Signal Transduction Basal Plasma Membrane Ephrin Receptor Binding Plasma Membrane Animal Organ Development Regulation Of Cellular Component Organization Receptor Complex Positive Regulation Of Cell Population Proliferation Protein Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Protein Tyrosine Kinase Activator Activity Shc-EGFR Complex ERBB3:ERBB2 Complex Kinase Activity Intracellular Signal Transduction
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