PLEK2

Description		pleckstrin 2
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Membrane Cell Projection
	Molecular Function	Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Intracellular Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
Pathways
Drugs
Diseases
GWAS		Broad depression or major depressive disorder (recurrent) ( 30626913) Depressive symptom measurement or major depressive disorder ( 28049566) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494)
Interacting Genes		1 interacting genes: INPPL1
Entrez ID		26499
HPRD ID		12151
Ensembl ID		ENSG00000100558
Uniprot IDs		Q9NYT0
PDB IDs		1X1G
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Ruffle Assembly Establishment Of Spindle Orientation Phospholipid Dephosphorylation Endochondral Ossification SH2 Domain Binding Phosphatidylinositol Dephosphorylation Establishment Of Mitotic Spindle Localization Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Ruffle Organization Establishment Of Spindle Localization ERK1 And ERK2 Cascade Spindle Localization Basal Plasma Membrane Post-embryonic Development Filopodium Phosphatase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ossification Phosphatidylinositol Metabolic Process Glucose Metabolic Process SH3 Domain Binding Dephosphorylation Phosphatidylinositol Biosynthetic Process Microtubule Cytoskeleton Organization Involved In Mitosis Lipid Modification Hexose Metabolic Process Spindle Pole Response To Insulin Glycerophospholipid Biosynthetic Process Monosaccharide Metabolic Process Lamellipodium Phospholipid Biosynthetic Process
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