GAPDHS and CFLAR

		GAPDHS	CFLAR
Description		glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	CASP8 and FADD like apoptosis regulator
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding
	Biological Process	Glucose Metabolic Process Glycolytic Process Flagellated Sperm Motility Positive Regulation Of Glycolytic Process	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Association of TriC/CCT with target proteins during biosynthesis Glycolysis Gluconeogenesis	TRAIL signaling
Drugs		NADH Zinc (+)-Rutamarin alcohol N-naphthalen-1-ylmethyl-2'-[3,5-dimethoxybenzamido]-2'-deoxy-adenosine 2'-Deoxy-2'-[(3,5-dimethoxybenzoyl)amino]-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]adenosine Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Diastolic blood pressure ( 28234671) Platelet count ( 32888494) Plateletcrit ( 32888494) Systolic blood pressure ( 28234671)	Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)
Interacting Genes		4 interacting genes: ANXA1 APP SH3BP4 ZMYND19	34 interacting genes: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CUL1 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 MEX3B NEURL3 NFKB1 PSEN2 RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8
Entrez ID		26330	8837
HPRD ID		13566	04671
Ensembl ID		ENSG00000105679	ENSG00000003402
Uniprot IDs		A0A0K0K1K1 O14556	A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		3H9E 3PFW 5C7L 5C7O	2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Apoptotic Process Cellular Response To Glucocorticoid Stimulus Response To Growth Factor Cellular Response To Growth Factor Stimulus Endocytosis Cellular Response To Corticosteroid Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Clathrin-coated Pit Positive Regulation Of Programmed Cell Death Positive Regulation Of Mitotic Cell Cycle Response To Glucocorticoid Regulation Of Interleukin-1 Production Regulation Of Cell Population Proliferation Myeloid Leukocyte Activation Import Into Cell Response To Corticosteroid Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Skeletal Myofibril Assembly Negative Regulation Of Myoblast Fusion Amino Acid Import Myoblast Migration Involved In Skeletal Muscle Regeneration Positive Regulation Of Neutrophil Apoptotic Process Cytoplasmic Vesicle Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of T-helper 2 Cell Differentiation	Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production
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