TRDMT1 and SNRPD3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TRDMT1	SNRPD3
Description		tRNA aspartic acid methyltransferase 1	small nuclear ribonucleoprotein D3 polypeptide
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Commitment Complex Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Telomerase Holoenzyme Complex Cytoplasm Cytosol Nuclear Body Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Methyltransferase Activity TRNA Methyltransferase Activity TRNA (cytidine-5-)-methyltransferase Activity Transferase Activity	RNA Binding Protein Binding Enzyme Binding Telomerase RNA Binding Histone Pre-mRNA DCP Binding U7 SnRNA Binding
	Biological Process	TRNA Modification TRNA Processing TRNA Methylation Methylation TRNA Stabilization	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing Protein Methylation RNA Splicing 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly
Pathways		tRNA modification in the nucleus and cytosol	SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery
Drugs		Pentamidine S-adenosyl-L-homocysteine Glycerin
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Telomere length ( 24478790)	Acne (severe) ( 24927181) Gamma glutamyl transferase levels ( 32084209)
Interacting Genes		14 interacting genes: APP COPS6 DDX24 EEF1A1 GBE1 LRIF1 NFRKB RBM48 SETDB1 SNRPD3 STX1A TBC1D2B UNC119 UTP14A	28 interacting genes: CASP8 CEBPA CRY1 DDX20 FNDC3B GEMIN2 GEMIN5 GEMIN6 GEMIN7 IL12RB1 IL7R LSM3 LSM7 NR1I3 NTAQ1 PRMT5 RBL1 SMN1 SMN2 SNRPB SNRPE SNRPG SREK1 STRAP STXBP2 STXBP3 TRDMT1 WDR77
Entrez ID		1787	6634
HPRD ID		16001	03039
Ensembl ID		ENSG00000107614	ENSG00000100028
Uniprot IDs		B4DQZ2 O14717 Q6ICS7 Q7Z3E4	P62318
PDB IDs		1G55	1D3B 3CW1 3JCR 3PGW 3VRI 4PJO 4WZJ 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6V4X 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y 7DVQ 7EVO 7QTT 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8R7N 8RC0 8RM5 8RO2 8Y6O 8Y7E 9FMD 9GBW 9GC0 9GCL
Enriched GO Terms of Interacting Partners?			SMN-Sm Protein Complex Spliceosomal SnRNP Assembly SMN Complex Protein-RNA Complex Assembly Gemini Of Cajal Bodies RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing MRNA Metabolic Process RNA Processing Spliceosomal Complex Assembly RNA Metabolic Process Methylosome MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex U2-type Precatalytic Spliceosome RNA Binding Protein-containing Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleoplasm U12-type Spliceosomal Complex Protein-containing Complex Organization U7 SnRNP 7-methylguanosine Cap Hypermethylation Catalytic Step 2 Spliceosome Macromolecule Metabolic Process U4 SnRNP Cellular Component Assembly Macromolecule Methylation Nucleus Nuclear Body Small Nuclear Ribonucleoprotein Complex Cytosol U2 SnRNP Binding U2-type Prespliceosome DNA-templated Transcription Termination U1 SnRNP Precatalytic Spliceosome U5 SnRNP RNA Methylation Tertiary Granule U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Presynaptic Dense Core Vesicle Exocytosis U2-type Catalytic Step 2 Spliceosome Methylation Lsm1-7-Pat1 Complex
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