ERAL1 and SSX2IP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ERAL1	SSX2IP
Description		Era like 12S mitochondrial rRNA chaperone 1	SSX family member 2 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane	Nucleus Cytoplasm Centrosome Cytoskeleton Adherens Junction Cell Leading Edge Protein-containing Complex Centriolar Satellite Ciliary Basal Body Cell Projection Anchoring Junction
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding GTP Binding RRNA Binding Ribosomal Small Subunit Binding	Protein Binding Protein Domain Specific Binding
	Biological Process	Ribosomal Small Subunit Assembly Ribosome Biogenesis	Centrosome Cycle Cell Adhesion Cell Projection Organization Regulation Of Rac Protein Signal Transduction Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Regulation Of Cell Motility
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs
Diseases
GWAS		Estimated glomerular filtration rate reduction (30%) ( 30955190) Glycated hemoglobin levels ( 28898252 34059833) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 29403010) Pulse pressure ( 30224653) Red cell distribution width ( 32888494)	Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		48 interacting genes: CEP44 ECT2 EXOSC8 MIR1-1 MIR106A MIR106B MIR107 MIR122 MIR138-1 MIR141 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR199A1 MIR199A2 MIR19A MIR19B1 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR29B2 MIR34B MIR451A MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7I SRSF4 SSX2IP	114 interacting genes: ABLIM3 ACTN1 ACTN2 AEN AFDN AP1M1 ARNT2 ATOSA BCL6 BEX2 BKGD BRCA1 BYSL CARD9 CCDC187 CCDC198 CCHCR1 CCNH CDC23 CDC42 CDCA7L CHCHD3 DAXX DRG1 DVL2 EAF2 EHHADH EIF4A2 ERAL1 FAM124B FAM161A FANCG FANCL FBF1 FNDC11 FRMD6 GEM GOLGA2 GOLGA8F GRAP2 HDAC4 HNRNPLL IKBKG INO80B KAT5 KDM1A KIF9 KIFC3 KLHL42 KRT15 KRT31 KRT40 KRTAP10-7 LATS1 LMO2 MCM7 MFAP1 MORN4 MOS MRPL53 NAA10 NDN NIF3L1 NOL12 NTAQ1 PHC2 PIMREG PKN1 PNMA1 POLL PRKAA1 PRKAB2 PRMT6 PRPF3 PRPF31 PSMA1 RAB1A RNF6 SCNM1 SHFL SSX2 SSX3 SYT17 TBP TEAD4 TFIP11 TOP3B TRIM42 TRIM54 TSGA10IP TSTD2 TTC23 WDR5 XIAP YWHAQ YWHAZ ZBTB24 ZFYVE26 ZGPAT ZMAT2 ZNF124 ZNF202 ZNF250 ZNF3 ZNF408 ZNF417 ZNF438 ZNF587 ZNF648 ZNF688 ZNF71 ZNF792 ZRSR2 ZSCAN12
Entrez ID		26284	117178
HPRD ID		08466	10566
Ensembl ID		ENSG00000132591	ENSG00000117155
Uniprot IDs		O75616	B7ZB07 Q9Y2D8
PDB IDs		8CSP 8CSQ
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Extracellular Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Regulation Of MRNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Migration Negative Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vasculature Development Negative Regulation Of Cell Motility Regulation Of Translation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Extracellular Space	Nucleus Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Zinc Ion Binding Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nuclear Androgen Receptor Binding Metal Ion Binding Regulation Of Metabolic Process DNA Damage Response DNA Recombination DNA-binding Transcription Factor Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Spliceosomal Complex Mitotic Spindle U2-type Precatalytic Spliceosome Keratin Filament MRNA Splicing, Via Spliceosome DNA Binding RNA Splicing, Via Transesterification Reactions Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleic Acid Metabolic Process AMP-activated Protein Kinase Activity Transcription Coactivator Activity Protein K6-linked Ubiquitination
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