ERAL1 and SRSF4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		ERAL1	SRSF4
Description		Era like 12S mitochondrial rRNA chaperone 1	serine and arginine rich splicing factor 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding GTP Binding RRNA Binding Ribosomal Small Subunit Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Sequence-specific MRNA Binding
	Biological Process	Ribosomal Small Subunit Assembly Ribosome Biogenesis	RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Insulin Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs			Artenimol
Diseases
GWAS		Estimated glomerular filtration rate reduction (30%) ( 30955190) Glycated hemoglobin levels ( 28898252 34059833) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 29403010) Pulse pressure ( 30224653) Red cell distribution width ( 32888494)	Carotid plaque maximum area ( 32469969) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean area of carotid plaque ( 32469969) Schizophrenia ( 26531332) Tourette syndrome ( 30818990)
Interacting Genes		48 interacting genes: CEP44 ECT2 EXOSC8 MIR1-1 MIR106A MIR106B MIR107 MIR122 MIR138-1 MIR141 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR199A1 MIR199A2 MIR19A MIR19B1 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR29B2 MIR34B MIR451A MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7I SRSF4 SSX2IP	28 interacting genes: CPSF7 DYRK1A ERAL1 FUS GEMIN2 HAP1 HTATSF1 NXF1 PNN PPARGC1A PRPF38A PRRC2B SART1 SCAF11 SMURF1 SMURF2 SREK1 SRPK1 SRRM2 SRRM4 SRSF10 SRSF2 SRSF6 TICAM1 TRA2B UBE2I USP7 ZDHHC17
Entrez ID		26284	6429
HPRD ID		08466	09052
Ensembl ID		ENSG00000132591	ENSG00000116350
Uniprot IDs		O75616	Q08170
PDB IDs		8CSP 8CSQ
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Extracellular Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Regulation Of MRNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Migration Negative Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vasculature Development Negative Regulation Of Cell Motility Regulation Of Translation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Extracellular Space	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Binding RNA Splicing, Via Transesterification Reactions Nuclear Speck RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleic Acid Binding Regulation Of MRNA Metabolic Process Spliceosomal Complex Assembly Nucleus Protein-containing Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Protein-containing Complex Organization Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process PML Body Cellular Component Assembly Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Pre-mRNA Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Binding Nuclear Export MRNA Splice Site Recognition Wnt Signaling Pathway, Planar Cell Polarity Pathway Histone H3T45 Kinase Activity SUMO Conjugating Enzyme Activity Positive Regulation Of Neurotrophin Production Maturation Of 5S RRNA Perforant Pathway To Dendrate Granule Cell Synapse Engulfment Of Target By Autophagosome Positive Regulation Of RNA Splicing Regulation Of Amyloid-beta Formation
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