FGF20 and PCM1

		FGF20	PCM1
Description		fibroblast growth factor 20	pericentriolar material 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium
	Molecular Function	Signaling Receptor Binding Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparan Sulfate Proteoglycan Binding Receptor-receptor Interaction	Protein Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Dopamine Secretion Neurogenesis Cell Differentiation Regulation Of Cell Migration Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Dopaminergic Neuron Differentiation	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Allergic rhinitis in asthma ( 25085501) Attention function in attention deficit hyperactive disorder ( 26174813) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels in HIV infection ( 33109212) Parkinson's disease ( 25064009) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)
Interacting Genes		1 interacting genes: PTX3	57 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PPIE PRC1 PRKCI PRPF6 RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TTC8 VPS26C WASHC3 ZNF830
Entrez ID		26281	5108
HPRD ID		05709	02624
Ensembl ID		ENSG00000078579	ENSG00000078674
Uniprot IDs		Q9NP95	A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154
PDB IDs		3F1R	6HYL 6HYM 7Q46
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Localization To Centriolar Satellite Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding Interkinetic Nuclear Migration Ovarian Cumulus Expansion Intraciliary Transport Involved In Cilium Assembly Complement Component C1q Complex Binding Regulation Of Protein Complex Stability Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Virion Binding Negative Regulation Of Glycoprotein Metabolic Process Opsonization Host-mediated Suppression Of Viral Proces Response To Yeast Pericentriolar Material Positive Regulation Of Transport Microtubule Anchoring Neuronal Stem Cell Population Maintenance Protein Localization To Centrosome Nuclear Migration Host-mediated Suppression Of Symbiont Invasion Nucleus Localization Non-motile Cilium Ciliary Transition Zone Ovulation Cycle Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Cytoskeleton Centrosome Cycle Intraciliary Transport Non-motile Cilium Assembly Social Behavior Tertiary Granule Lumen Specific Granule Lumen Response To Fungus Regulation Of Nitric Oxide Biosynthetic Process Cytoplasmic Microtubule Organization Regulation Of Nitric Oxide Metabolic Process Protein-containing Complex Localization Regulation Of Transport Positive Regulation Of Phagocytosis Host-mediated Perturbation Of Viral Process Negative Regulation Of Viral Process Microtubule Organizing Center Organization Apical Part Of Cell Identical Protein Binding Positive Regulation Of Intracellular Protein Transport Regulation Of Phagocytosis Host-mediated Perturbation Of Symbiont Process	Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly
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