FGF20

Description		fibroblast growth factor 20
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Signaling Receptor Binding Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparan Sulfate Proteoglycan Binding Receptor-receptor Interaction
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Dopamine Secretion Neurogenesis Cell Differentiation Regulation Of Cell Migration Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Dopaminergic Neuron Differentiation
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
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Diseases
GWAS		Allergic rhinitis in asthma ( 25085501) Attention function in attention deficit hyperactive disorder ( 26174813) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels in HIV infection ( 33109212) Parkinson's disease ( 25064009) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Novel Interacting Genes		1 novel interacting genes: PCM1
Interacting Genes		1 interacting genes: PTX3
Entrez ID		26281
HPRD ID		05709
Ensembl ID		ENSG00000078579
Uniprot IDs		Q9NP95
PDB IDs		3F1R
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Localization To Centriolar Satellite Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding Interkinetic Nuclear Migration Ovarian Cumulus Expansion Intraciliary Transport Involved In Cilium Assembly Complement Component C1q Complex Binding Regulation Of Protein Complex Stability Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Virion Binding Negative Regulation Of Glycoprotein Metabolic Process Opsonization Host-mediated Suppression Of Viral Proces Response To Yeast Pericentriolar Material Positive Regulation Of Transport Microtubule Anchoring Neuronal Stem Cell Population Maintenance Protein Localization To Centrosome Nuclear Migration Host-mediated Suppression Of Symbiont Invasion Nucleus Localization Non-motile Cilium Ciliary Transition Zone Ovulation Cycle Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Cytoskeleton Centrosome Cycle Intraciliary Transport Non-motile Cilium Assembly Social Behavior Tertiary Granule Lumen Specific Granule Lumen Response To Fungus Regulation Of Nitric Oxide Biosynthetic Process Cytoplasmic Microtubule Organization Regulation Of Nitric Oxide Metabolic Process Protein-containing Complex Localization Regulation Of Transport Positive Regulation Of Phagocytosis Host-mediated Perturbation Of Viral Process Negative Regulation Of Viral Process Microtubule Organizing Center Organization Apical Part Of Cell Identical Protein Binding Positive Regulation Of Intracellular Protein Transport Regulation Of Phagocytosis Host-mediated Perturbation Of Symbiont Process
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