VPS33B and TNIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		VPS33B	TNIP1
Description		VPS33B late endosome and lysosome associated	TNFAIP3 interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Clathrin-coated Vesicle HOPS Complex Platelet Alpha Granule Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Recycling Endosome Vesicle Tethering Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Intracellular Protein Transport Endosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Peptidyl-lysine Hydroxylation Collagen Fibril Organization Melanosome Localization Lysosome Localization Collagen Metabolic Process Megakaryocyte Development Skin Morphogenesis Membrane Fusion Platelet Alpha Granule Organization Regulation Of Platelet Aggregation Phagosome-lysosome Fusion Autophagosome Maturation	MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Translation Defense Response Inflammatory Response Leukocyte Cell-cell Adhesion Glycoprotein Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Regulation Of Primary Metabolic Process Positive Regulation Of Protein Deubiquitination
Pathways		Prevention of phagosomal-lysosomal fusion SARS-CoV-2 modulates autophagy	Ovarian tumor domain proteases
Drugs
Diseases		Arthrogryposis, renal dysfunction, and cholestasis; ARC syndrome
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Feeling hurt ( 29500382) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Red cell distribution width ( 32888494)	Amyotrophic lateral sclerosis ( 29566793) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Cutaneous psoriasis ( 26626624) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Myasthenia gravis ( 23055271) Neutrophil percentage of granulocytes ( 27863252) Psoriasis ( 25903422 25854761 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624 29031612) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596) Serum alkaline phosphatase levels ( 33547301) Sjögren's syndrome ( 24097067) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26606652 26502338 23273568 19838195 33272962 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 29293537 30572963 31672989 21750679) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		6 interacting genes: APP MAP3K20 MAPK8IP2 TNIP1 UVRAG VIPAS39	88 interacting genes: ABHD17A ADH6 AP1M1 BYSL C8orf33 CCDC112 CCDC121 CCNG1 CDC23 CDC37 CDIP1 CDKN1A CFAP53 CYSRT1 DAZAP2 DPPA4 EFEMP1 EHHADH ELOA FAM161A FAM168A GABARAP GABARAPL1 GABARAPL2 GIT2 GTF2B GTF2H1 IKBKG KIFC3 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LENG8 LITAF MAGEB18 MAGEH1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MAPK1 MAPK10 MCM10 MCRS1 MOB1B MOB3C MORF4L1 MORF4L2 NIFK NME7 NOD2 PIBF1 PNKP RABAC1 RALBP1 RARA RARG RBFOX1 RNF11 RNF8 RPL5 S100B SELPLG SHTN1 SNIP1 SPATA2 SUMO2 SYT6 TBK1 TCEA2 TCEANC TCEANC2 TNFAIP3 TNIP3 TTC39A TTF2 TXLNA TYRO3 UBC VPS33B WTAP ZBTB25 ZMAT2 ZNHIT1
Entrez ID		26276	10318
HPRD ID		10541	09216
Ensembl ID		ENSG00000184056	ENSG00000145901
Uniprot IDs		A0A0S2Z577 B7Z1N4 F5H008 Q9H267	A0A0A0MRZ4 A8K4N4 B7Z8K2 Q15025
PDB IDs			7EAL 7EAO 7EB9 8YFK 8YFL 8YFM 8YFN 9D34
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Organization Mating Behavior Early Endosome Modulation Of Excitatory Postsynaptic Potential Reproductive Behavior Autophagosome Maturation Regulation Of Stress-activated Protein Kinase Signaling Cascade Protein Kinase Activator Activity JNK Cascade Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Lytic Vacuole Positive Regulation Of Mitotic DNA Damage Checkpoint Protein-containing Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Recycling Endosome Response To Stress Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response Lipoprotein Particle Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Chromosome Segregation Protein-containing Complex Disassembly Maintenance Of Golgi Location Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of JNK Cascade Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Learning Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Protein Binding Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Cellular Response To Starvation Cellular Response To Nutrient Levels Autophagosome Assembly Protein-containing Complex Disassembly Autophagosome Organization Response To Starvation Macroautophagy Intermediate Filament Cytoplasmic Side Of Late Endosome Membrane Response To Nutrient Levels Phospholipid Binding Nucleoplasm Organelle Assembly Positive Regulation Of DNA Repair GABA Receptor Binding Regulation Of Protein Modification Process Positive Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Trachea Cartilage Development Autophagy Negative Regulation Of Canonical NF-kappaB Signal Transduction Face Development Glandular Epithelial Cell Development Regulation Of Canonical NF-kappaB Signal Transduction Vacuole Organization DNA-templated Transcription Intestinal Stem Cell Homeostasis Regulation Of Cellular Response To Stress Cytosol Protein Modification Process Negative Regulation Of Cartilage Development Nucleus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Damage Response Regulation Of Protein Phosphorylation Ciliary Basal Body Beta-tubulin Binding
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