VPS33B and VIPAS39

Number of citations of the paper that reports this interaction (PubMedID 29778605)
65

Data Source:
BioGRID (biochemical, affinity chromatography technology, proximity labelling technology)
HPRD (two hybrid)

		VPS33B	VIPAS39
Description		VPS33B late endosome and lysosome associated	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Clathrin-coated Vesicle HOPS Complex Platelet Alpha Granule Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Recycling Endosome Vesicle Tethering Complex	Cytoplasm Endosome Early Endosome Late Endosome Golgi Apparatus HOPS Complex Cytoplasmic Vesicle Recycling Endosome Vesicle Tethering Complex
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding Protein-containing Complex Binding
	Biological Process	Intracellular Protein Transport Endosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Peptidyl-lysine Hydroxylation Collagen Fibril Organization Melanosome Localization Lysosome Localization Collagen Metabolic Process Megakaryocyte Development Skin Morphogenesis Membrane Fusion Platelet Alpha Granule Organization Regulation Of Platelet Aggregation Phagosome-lysosome Fusion Autophagosome Maturation	Intracellular Protein Transport Vacuolar Transport Spermatogenesis Endosome To Lysosome Transport Protein Transport Peptidyl-lysine Hydroxylation Cell Differentiation Collagen Fibril Organization Collagen Metabolic Process Post-translational Protein Modification Phagosome-lysosome Fusion Autophagosome Maturation
Pathways		Prevention of phagosomal-lysosomal fusion SARS-CoV-2 modulates autophagy
Drugs
Diseases		Arthrogryposis, renal dysfunction, and cholestasis; ARC syndrome	Arthrogryposis, renal dysfunction, and cholestasis; ARC syndrome
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Feeling hurt ( 29500382) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Red cell distribution width ( 32888494)	Apolipoprotein A1 levels ( 32203549)
Interacting Genes		6 interacting genes: APP MAP3K20 MAPK8IP2 TNIP1 UVRAG VIPAS39	2 interacting genes: OGT VPS33B
Entrez ID		26276	63894
HPRD ID		10541	10710
Ensembl ID		ENSG00000184056	ENSG00000151445
Uniprot IDs		A0A0S2Z577 B7Z1N4 F5H008 Q9H267	B4DMB7 Q6IA61 Q9H9C1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Organization Mating Behavior Early Endosome Modulation Of Excitatory Postsynaptic Potential Reproductive Behavior Autophagosome Maturation Regulation Of Stress-activated Protein Kinase Signaling Cascade Protein Kinase Activator Activity JNK Cascade Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Lytic Vacuole Positive Regulation Of Mitotic DNA Damage Checkpoint Protein-containing Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Recycling Endosome Response To Stress Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response Lipoprotein Particle Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Chromosome Segregation Protein-containing Complex Disassembly Maintenance Of Golgi Location Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of JNK Cascade Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Learning Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling	Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Hemopoiesis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Vesicle Tethering Complex CORVET Complex Platelet Alpha Granule Organization Peptidyl-lysine Hydroxylation Regulation Of Transcription By Glucose NSL Complex Skin Morphogenesis Phagosome-lysosome Fusion HOPS Complex Protein Hydroxylation Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Platelet Alpha Granule Histone Acetyltransferase Complex Sin3-type Complex Cell Development Negative Regulation Of Stem Cell Population Maintenance Pigment Granule Localization Melanosome Localization Megakaryocyte Development Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Regulation Of Platelet Aggregation Regulation Of Necroptotic Process Regulation Of Rac Protein Signal Transduction Phosphatidylinositol-3,4,5-trisphosphate Binding Cellular Response To Nutrient Regulation Of Programmed Necrotic Cell Death Mitophagy Protein Localization To Lysosome Circadian Regulation Of Gene Expression Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Glucose Stimulus Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Gluconeogenesis Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Pyroptotic Inflammatory Response
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