HHEX and SOX8

Number of citations of the paper that reports this interaction (PMID 16582099)
41

Data Source:
HPRD (two hybrid)

		HHEX	SOX8
Gene Name		hematopoietically expressed homeobox	SRY (sex determining region Y)-box 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Protein-DNA Complex	Nucleus Cytoplasm Nuclear Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Transcription Factor Binding Eukaryotic Initiation Factor 4E Binding DNA Binding, Bending TBP-class Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Repressing Transcription Factor Binding HMG Box Domain Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Transcription Factor Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis In Utero Embryonic Development Myeloid Leukocyte Differentiation Transcription, DNA-templated MRNA Export From Nucleus Endoderm Development Cell Proliferation Response To Wounding Anterior/posterior Pattern Specification Negative Regulation Of Transcription By Transcription Factor Localization Negative Regulation Of Transcription By Competitive Promoter Binding Wnt Signaling Pathway Negative Regulation Of Angiogenesis Poly(A)+ MRNA Export From Nucleus Interkinetic Nuclear Migration Cell Differentiation Positive Regulation Of Wnt Signaling Pathway B Cell Differentiation Thyroid Gland Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Pancreas Development Protein Localization To Nucleus Embryonic Heart Tube Development Multicellular Organism Growth Regulation Of Cell Proliferation Response To Peptide Hormone Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Forebrain Morphogenesis Primary Lung Bud Formation Gall Bladder Development Hepatic Duct Development Hepatoblast Differentiation Hepatocyte Differentiation DNA Conformation Change Primitive Streak Formation	Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways
Drugs
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175) Multiple sclerosis ( 21833088) Type 2 diabetes ( 18372903 17293876 22693455 20862305 20581827 19401414 17463246 17463248 17463249)	Multiple sclerosis ( 21833088)
Protein-Protein Interactions		15 interactors: EFEMP2 GATA2 GATA6 JUN KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP4-12 PML PSMA3 SOX10 SOX8 TLE1 TRMT6	18 interactors: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1
Entrez ID		3087	30812
HPRD ID		06829	16175
Ensembl ID			ENSG00000005513
Uniprot IDs		Q03014	P57073
PDB IDs		2E1O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Organ Morphogenesis Positive Regulation Of Cell Cycle Arrest RNA Metabolic Process Cell Fate Commitment SMAD Protein Import Into Nucleus Tube Development Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Cell Cycle Arrest RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Macromolecule Biosynthetic Process Enteric Nervous System Development Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cell Maturation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Gland Development In Utero Embryonic Development Epithelium Development Organ Development Epithelial Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Process Regulation Of Gene Expression	Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Regulation Of Gene Expression RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process System Development Cell Differentiation Tissue Development Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gland Development Developmental Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Liver Development Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process Embryonic Organ Development Positive Regulation By Host Of Viral Transcription Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Myeloid Cell Differentiation Heart Development Endoderm Development
Tagcloud ?		beyond circulation clp definitive deleted dendritic deregulated developmental functioning hematopoiesis hematopoietic hematopoietically homeobox knockout lineages lymphoid nk null overexpressed precursors progenitors progressive regulators rescue spleen stem subsets tolerated transitional	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Difference) ?		beyond circulation clp definitive deleted dendritic deregulated developmental functioning hematopoiesis hematopoietic hematopoietically homeobox knockout lineages lymphoid nk null overexpressed precursors progenitors progressive regulators rescue spleen stem subsets tolerated transitional	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Intersection) ?