HHEX and TRMT6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HHEX	TRMT6
Description		hematopoietically expressed homeobox	tRNA methyltransferase 6 non-catalytic subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Body Protein-DNA Complex	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Eukaryotic Initiation Factor 4E Binding DNA Binding, Bending TBP-class Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Translation Regulator Activity DNA-binding Transcription Factor Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Regulation Of MRNA Export From Nucleus Negative Regulation Of Transcription By Competitive Promoter Binding Wnt Signaling Pathway Negative Regulation Of Angiogenesis Cell Differentiation Positive Regulation Of Wnt Signaling Pathway B Cell Differentiation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Proliferation DNA Conformation Change Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cytoplasmic Translational Initiation	MRNA Processing TRNA Processing TRNA Methylation
Pathways		Developmental Lineage of Multipotent Pancreatic Progenitor Cells	tRNA modification in the nucleus and cytosol
Drugs
Diseases		Type II diabetes mellitus
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 31619474) Birth weight ( 31043758 27680694) Body mass index ( 28892062) Circulating leptin levels or type 2 diabetes ( 32341051) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hemoglobin A1c levels ( 29403010) Inflammatory bowel disease ( 28067908) Insulin disposition index ( 24699409) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 29785010) Multiple sclerosis ( 24076602 21833088 31604244) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Type 2 diabetes ( 32499647 30054458 30297969 30718926 29358691 17293876 28869590 26818947 24509480 23945395 22885922 22693455 20862305 20581827 19401414 18372903 17463249 17463248 17463246)	ghrelin levels ( 33852427) Menarche and menopause (age at onset) ( 19448621) Uterine fibroids ( 31649266)
Interacting Genes		41 interacting genes: ABI1 ABI2 APOBEC3C CYSRT1 EFEMP2 GATA2 GATA6 JUN KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP19-1 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 MDFI NBPF19 NOTCH2NLA PFDN5 PML PSMA3 PSTPIP1 RBMY1F RBMY1J SOX10 SOX8 TLE1 TLE5 TP53BP2 TRMT6	4 interacting genes: FOXJ1 HHEX OGT TRMT61A
Entrez ID		3087	51605
HPRD ID		06829	13027
Ensembl ID		ENSG00000152804	ENSG00000089195
Uniprot IDs		Q03014	Q9UJA5
PDB IDs		2E1O	5CCB 5CCX 5CD1
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Negative Regulation Of Wnt Signaling Pathway Cytosol Negative Regulation Of RNA Biosynthetic Process SH3 Domain Binding Actin-based Cell Projection Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Enteric Nervous System Development SCAR Complex Anatomical Structure Morphogenesis Keratinization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Filopodium Tip	Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction Regulation Of Translational Initiation Negative Regulation Of Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Negative Regulation Of Cytoplasmic Translational Initiation MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity Negative Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translation Protein O-acetylglucosaminyltransferase Activity TRNA (m1A) Methyltransferase Complex Metanephric Part Of Ureteric Bud Development Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Ciliary Basal Body Organization Regulation Of Leukocyte Proliferation Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Regionalization Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Germinal Center Formation Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By Glucose Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of MRNA Export From Nucleus Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Tolerance Induction Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway NSL Complex Left/right Pattern Formation Negative Regulation Of Transcription By Competitive Promoter Binding
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