HHEX and TRMT6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HHEX	TRMT6
Gene Name		hematopoietically expressed homeobox	tRNA methyltransferase 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Protein-DNA Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Transcription Factor Binding Eukaryotic Initiation Factor 4E Binding DNA Binding, Bending TBP-class Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Repressing Transcription Factor Binding HMG Box Domain Binding	Translation Initiation Factor Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis In Utero Embryonic Development Myeloid Leukocyte Differentiation Transcription, DNA-templated MRNA Export From Nucleus Endoderm Development Cell Proliferation Response To Wounding Anterior/posterior Pattern Specification Negative Regulation Of Transcription By Transcription Factor Localization Negative Regulation Of Transcription By Competitive Promoter Binding Wnt Signaling Pathway Negative Regulation Of Angiogenesis Poly(A)+ MRNA Export From Nucleus Interkinetic Nuclear Migration Cell Differentiation Positive Regulation Of Wnt Signaling Pathway B Cell Differentiation Thyroid Gland Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Pancreas Development Protein Localization To Nucleus Embryonic Heart Tube Development Multicellular Organism Growth Regulation Of Cell Proliferation Response To Peptide Hormone Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Forebrain Morphogenesis Primary Lung Bud Formation Gall Bladder Development Hepatic Duct Development Hepatoblast Differentiation Hepatocyte Differentiation DNA Conformation Change Primitive Streak Formation	Translational Initiation Regulation Of Translational Initiation TRNA Processing
Pathways
Drugs
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175) Multiple sclerosis ( 21833088) Type 2 diabetes ( 18372903 17293876 22693455 20862305 20581827 19401414 17463246 17463248 17463249)	Menarche and menopause (age at onset) ( 19448621)
Protein-Protein Interactions		15 interactors: EFEMP2 GATA2 GATA6 JUN KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP4-12 PML PSMA3 SOX10 SOX8 TLE1 TRMT6	3 interactors: FOXJ1 HHEX TRMT61A
Entrez ID		3087	51605
HPRD ID		06829	13027
Ensembl ID			ENSG00000089195
Uniprot IDs		Q03014	B4DUV6 Q9UJA5
PDB IDs		2E1O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Organ Morphogenesis Positive Regulation Of Cell Cycle Arrest RNA Metabolic Process Cell Fate Commitment SMAD Protein Import Into Nucleus Tube Development Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Cell Cycle Arrest RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Macromolecule Biosynthetic Process Enteric Nervous System Development Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cell Maturation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Gland Development In Utero Embryonic Development Epithelium Development Organ Development Epithelial Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Process Regulation Of Gene Expression	Positive Regulation Of Lung Ciliated Cell Differentiation Central Tolerance Induction Hepatic Duct Development Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction Hepatoblast Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Lung Development Respiratory Tube Development Gall Bladder Development Glomerular Parietal Epithelial Cell Differentiation Negative Regulation Of Transcription By Transcription Factor Localization Respiratory System Development Primary Lung Bud Formation Metanephric Part Of Ureteric Bud Development Negative Regulation Of Interleukin-6 Biosynthetic Process Common Bile Duct Development Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Establishment Of Apical/basal Cell Polarity Tolerance Induction Negative Regulation Of Transcription By Competitive Promoter Binding Pattern Specification Process Establishment Of Monopolar Cell Polarity Negative Regulation Of T Cell Differentiation In Thymus Primitive Streak Formation Poly(A)+ MRNA Export From Nucleus Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Epithelial Cell Differentiation Regulation Of Germinal Center Formation Hepatocyte Differentiation Interkinetic Nuclear Migration RNA Metabolic Process Immune System Development Tube Development Forebrain Morphogenesis Regulation Of Interleukin-6 Biosynthetic Process Left/right Pattern Formation TRNA Methylation Brain Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Thyroid Gland Development Head Development Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of T Cell Differentiation In Thymus Metanephros Morphogenesis Negative Regulation Of Protein Metabolic Process
Tagcloud ?		beyond circulation clp definitive deleted dendritic deregulated developmental functioning hematopoiesis hematopoietic hematopoietically homeobox knockout lineages lymphoid nk null overexpressed precursors progenitors progressive regulators rescue spleen stem subsets tolerated transitional
Tagcloud (Difference) ?		beyond circulation clp definitive deleted dendritic deregulated developmental functioning hematopoiesis hematopoietic hematopoietically homeobox knockout lineages lymphoid nk null overexpressed precursors progenitors progressive regulators rescue spleen stem subsets tolerated transitional
Tagcloud (Intersection) ?