LMO1 and BCL11A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		LMO1	BCL11A
Description		LIM domain only 1	BCL11 transcription factor A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Matrix SWI/SNF Complex Paraspeckles Postsynapse
	Molecular Function	Transcription Coactivator Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulatory Region Nucleic Acid Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Protein Sumoylation Negative Regulation Of Axon Extension Negative Regulation Of Protein Homooligomerization Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Collateral Sprouting Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Development Negative Regulation Of Dendrite Extension Negative Regulation Of Neuron Remodeling Cellular Response To L-glutamate Negative Regulation Of Dendrite Development Negative Regulation Of Branching Morphogenesis Of A Nerve
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs	ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Alcohol consumption ( 23743675) Body mass index ( 31888951 26426971 28892062) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Diastolic blood pressure ( 27618447) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Height ( 31562340) Malaria ( 31844061) Neuroblastoma ( 22941191 21124317) Offspring birth weight ( 31043758) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Restless legs syndrome ( 33239738) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 27618447)	Acne (severe) ( 30542056 24927181) Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder ( 22012869) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Beta thalassemia/hemoglobin E disease ( 20183929) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epilepsy ( 30531953) F-cell distribution ( 17767159) F-cell distribution in sickle cell anaemia ( 21326311) Face memory ( 31596458) Falling risk ( 32999390) Fetal hemoglobin levels ( 18245381 20018918) Fetal hemoglobin levels in sickle cell anemia ( 25372704) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Hemoglobin A2 levels in sickle cell anemia ( 25042611) Hemoglobin levels ( 26366553) High fetal hemoglobin in sickle cell disease ( 27022141) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Immature fraction of reticulocytes ( 27863252 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494 19862010 28017375 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Methadone dose in opioid dependence ( 28115739) Monocyte early outgrowth colony forming units ( 21493818) Morning person ( 30696823) Number of sexual partners ( 30643258) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 27863252 32888494) Refractive error ( 32231278) Resting heart rate ( 27798624) Risk-taking tendency (4-domain principal component model) ( 30643258) Sickle cell anemia (haemolysis) ( 23406172) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 1 diabetes ( 34012112) Type 2 diabetes ( 28869590 30297969 29358691 30718926 20581827 22885922 32499647 24509480) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Walking pace ( 33128006)
Interacting Genes		122 interacting genes: ABI1 ABI2 ADAMTSL4 AKAP9 AKNA ASB15 BANP BCAS2 BCL11A BIVM BLZF1 BNC2 BYSL CARD9 CBY2 CCDC33 CCDC88B CDCA7L CDX4 CEP170P1 CEP44 CEP57L1 CHCHD3 DDIT4L DRC4 ERBIN EVI5 FBXO16 GABPB1 GATA3 GOLGA2 GPATCH2L GPRASP3 HDX HGS HMBOX1 HMG20A HNRNPH1 HNRNPM HOMEZ HSPB2 HSPB2-C11orf52 IKZF1 IKZF3 ISY1 KANK2 KCTD1 KIAA1328 KRABD4 KRT16 KRT40 KRT75 LDB1 LDB2 LPXN LYL1 LZTS1 LZTS2 MAD1L1 MBD3L1 MEOX2 MISP MSS51 NAGK NDUFA7 NHLH1 NTAQ1 NUTM1 PHC2 PICK1 POLR3GL PPP1R13B PRDM6 PSMB1 PTPN3 PXN RBBP8 RCN1 REL SAXO1 SNTA1 SOX5 SPG21 SYTL4 TADA2A TAL1 TAL2 TASOR2 TCF4 TCP10L TFIP11 TLE5 TRIM27 TRIM35 TRIM54 TSC22D4 UFSP2 UHMK1 UNKL UTP14A VBP1 WASHC1 ZBTB43 ZBTB8B ZCCHC12 ZFP90 ZNF143 ZNF177 ZNF19 ZNF219 ZNF24 ZNF354C ZNF417 ZNF460 ZNF511 ZNF526 ZNF559-ZNF177 ZNF620 ZNF641 ZNF688 ZNF76 ZNF84	25 interacting genes: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 EZH2 FXR2 GMCL2 LMO1 MORF4L2 NCK2 NFAM1 NR2E3 NR2F1 NR2F2 NR2F6 PIN1 SIN3A SIRT1 SUZ12 TSC1 UBE2I YME1L1 ZBTB24
Entrez ID		4004	53335
HPRD ID		01738	05949
Ensembl ID		ENSG00000166407	ENSG00000119866
Uniprot IDs		E9PK83 P25800	A0A2R8Y2E8 A0A2U3TZJ5 B4DT16 D9YZV9 D9YZW0 Q9H165
PDB IDs			5VTB 6KI6 6U9Q 8DTN 8DTU 8THO 8TLO 9B4P 9BV0
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA Binding Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Actin Nucleation Negative Regulation Of Metabolic Process Identical Protein Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Response To Muramyl Dipeptide Cytoskeleton Negative Regulation Of Macromolecule Biosynthetic Process Metal Ion Binding Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Macromolecule Metabolic Process Cellular Developmental Process Developmental Process Regulation Of Mitotic Cell Cycle Chromatin Silencing Complex Regulation Of Cell Population Proliferation Nuclear Receptor Activity Facultative Heterochromatin Formation Regulation Of Cell Cycle Regulation Of Primary Metabolic Process ESC/E(Z) Complex Heterochromatin Formation Epigenetic Regulation Of Gene Expression Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cellular Senescence Mononuclear Cell Differentiation Regulation Of Cell Motility Regulation Of Locomotion Leukocyte Activation HLH Domain Binding Leukocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Lymphocyte Differentiation Positive Regulation Of Response To Endoplasmic Reticulum Stress Cell Activation Cellular Response To Stress
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