LMO1 and TAL2

Number of citations of the paper that reports this interaction (PubMedID 7957052)
65

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		LMO1	TAL2
Description		LIM domain only 1	TAL bHLH transcription factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin
	Molecular Function	Transcription Coactivator Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation	Regulation Of Transcription By RNA Polymerase II Post-embryonic Development Thalamus Development Midbrain Development Multicellular Organism Growth
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
GWAS		Alcohol consumption ( 23743675) Body mass index ( 31888951 26426971 28892062) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Diastolic blood pressure ( 27618447) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Height ( 31562340) Malaria ( 31844061) Neuroblastoma ( 22941191 21124317) Offspring birth weight ( 31043758) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Restless legs syndrome ( 33239738) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 27618447)	Cognitive performance ( 20125193) Cutaneous malignant melanoma ( 26237428) Melanoma ( 28212542) Menarche (age at onset) ( 19448620) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		122 interacting genes: ABI1 ABI2 ADAMTSL4 AKAP9 AKNA ASB15 BANP BCAS2 BCL11A BIVM BLZF1 BNC2 BYSL CARD9 CBY2 CCDC33 CCDC88B CDCA7L CDX4 CEP170P1 CEP44 CEP57L1 CHCHD3 DDIT4L DRC4 ERBIN EVI5 FBXO16 GABPB1 GATA3 GOLGA2 GPATCH2L GPRASP3 HDX HGS HMBOX1 HMG20A HNRNPH1 HNRNPM HOMEZ HSPB2 HSPB2-C11orf52 IKZF1 IKZF3 ISY1 KANK2 KCTD1 KIAA1328 KRABD4 KRT16 KRT40 KRT75 LDB1 LDB2 LPXN LYL1 LZTS1 LZTS2 MAD1L1 MBD3L1 MEOX2 MISP MSS51 NAGK NDUFA7 NHLH1 NTAQ1 NUTM1 PHC2 PICK1 POLR3GL PPP1R13B PRDM6 PSMB1 PTPN3 PXN RBBP8 RCN1 REL SAXO1 SNTA1 SOX5 SPG21 SYTL4 TADA2A TAL1 TAL2 TASOR2 TCF4 TCP10L TFIP11 TLE5 TRIM27 TRIM35 TRIM54 TSC22D4 UFSP2 UHMK1 UNKL UTP14A VBP1 WASHC1 ZBTB43 ZBTB8B ZCCHC12 ZFP90 ZNF143 ZNF177 ZNF19 ZNF219 ZNF24 ZNF354C ZNF417 ZNF460 ZNF511 ZNF526 ZNF559-ZNF177 ZNF620 ZNF641 ZNF688 ZNF76 ZNF84	9 interacting genes: CBFA2T2 LMO1 LMO2 MAPK3 PCBD2 RUNX1T1 TCF12 TCF3 TCF4
Entrez ID		4004	6887
HPRD ID		01738	01735
Ensembl ID		ENSG00000166407	ENSG00000186051
Uniprot IDs		E9PK83 P25800	Q16559
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA Binding Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Actin Nucleation Negative Regulation Of Metabolic Process Identical Protein Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Response To Muramyl Dipeptide Cytoskeleton Negative Regulation Of Macromolecule Biosynthetic Process Metal Ion Binding Regulation Of Arp2/3 Complex-mediated Actin Nucleation	DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process BHLH Transcription Factor Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuron Differentiation Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Dimerization Activity Regulation Of Metabolic Process Regulation Of Neuron Differentiation Regulation Of Lymphocyte Activation Positive Regulation Of Metabolic Process Regulation Of Cell Activation Nucleoplasm Cyclin D2-CDK6 Complex Regulation Of Leukocyte Proliferation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Glial Cell Development Negative Regulation Of RNA Metabolic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Heterodimerization Activity Cis-regulatory Region Sequence-specific DNA Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Cell Differentiation Regulation Of Immune System Process Regulation Of T Cell Activation Regulation Of T Cell Homeostatic Proliferation Interleukin-34-mediated Signaling Pathway Beta-catenin-TCF7L2 Complex Vitamin D Response Element Binding
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